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Literature DB >> 17505552

New roles for interleukin-1 Beta in the mechanisms of epilepsy.

Abstract

The mechanisms that transform a normal brain to an epileptic one are not fully understood. Interleukin-1 beta (IL-1beta) contributes to neuronal degeneration observed in several neurological disorders and recently has been implicated in neuronal injury that may accompany the process of epileptogenesis. This review presents the hypothesis that IL-1beta may contribute to the development of epilepsy via several mechanisms, including classical effects on neuronal survival and transcription pathways; novel rapid effects on receptor-gated ion channels; and long-lasting effects on expression of selective gene families. Thus, evidence that IL-1beta actions in epilepsy can be independent from the neurotoxic effects of this cytokine is presented.

Entities: Disease Gene

Year: 2007 PMID： 17505552 PMCID： PMC1867084 DOI： 10.1111/j.1535-7511.2007.00165.x

Source DB: PubMed Journal: Epilepsy Curr ISSN： 1535-7511 Impact factor: 7.500

48 in total

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Journal: Epilepsia Date: 2006-07 Impact factor: 5.864

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Journal: J Child Neurol Date: 2002-10 Impact factor: 1.987

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Authors: Manuel Sanchez-Alavez; Iustin V Tabarean; M Margarita Behrens; Tamas Bartfai
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Authors: Miia Virta; Mikko Hurme; Merja Helminen
Journal: Epilepsia Date: 2002-08 Impact factor: 5.864

74 in total

1. Upregulation of adenosine kinase in astrocytes in experimental and human temporal lobe epilepsy.

Authors: Eleonora Aronica; Emanuele Zurolo; Anand Iyer; Marjolein de Groot; Jasper Anink; Caterina Carbonell; Erwin A van Vliet; Johannes C Baayen; Detlev Boison; Jan A Gorter
Journal: Epilepsia Date: 2011-06-02 Impact factor: 5.864

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Authors: Detlev Boison
Journal: Open Neurosci J Date: 2010-01-01

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Authors: Annamaria Vezzani; Jacqueline French; Tamas Bartfai; Tallie Z Baram
Journal: Nat Rev Neurol Date: 2010-12-07 Impact factor: 42.937

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Authors: Wolfgang Löscher; Claudia Brandt
Journal: Pharmacol Rev Date: 2010-12 Impact factor: 25.468