BACKGROUND: Epidermal growth factor receptor (EGFR) gene mutations are frequently found in pulmonary adenocarcinomas. MATERIALS AND METHODS: Various lung cancers (n=30) including 8 small adenocarcinomas were examined for EGFR gene mutations in three exons. RESULTS: Mutations were detected in 32% of adenocarcinomas. Exon 19 mutations were detected in 5 tumors, often advanced stages: 1 in Noguchi's pathologic type C, 2 in type D, and 2 in type F. Exon 21 mutations were detected in 3 tumors, all small adenocarcinomas in type C, at pathologic stage IA. CONCLUSION: We suspect that exon 21 mutations are early events in small bronchioloalveolar carcinomas, while exon 19 mutations are later events occurring in adenocarcinomas of various types.
BACKGROUND:Epidermal growth factor receptor (EGFR) gene mutations are frequently found in pulmonary adenocarcinomas. MATERIALS AND METHODS: Various lung cancers (n=30) including 8 small adenocarcinomas were examined for EGFR gene mutations in three exons. RESULTS: Mutations were detected in 32% of adenocarcinomas. Exon 19 mutations were detected in 5 tumors, often advanced stages: 1 in Noguchi's pathologic type C, 2 in type D, and 2 in type F. Exon 21 mutations were detected in 3 tumors, all small adenocarcinomas in type C, at pathologic stage IA. CONCLUSION: We suspect that exon 21 mutations are early events in small bronchioloalveolar carcinomas, while exon 19 mutations are later events occurring in adenocarcinomas of various types.
Authors: Albrecht Stenzinger; Jörn Sträter; Martin Faehling; Birgit Schwenk; Sebastian Kramberg; Robert Eckert; Anna-Lena Volckmar Journal: Oncotarget Date: 2017-09-13