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Literature DB >> 17504653

Controlled trials in pediatric migraine: crossover versus parallel group.

Abstract

Studies on the treatment of migraine in children and adolescents are rare and difficult to design. In particular, the high placebo response makes it difficult to show efficacy of a verum drug. When analyzing all published trials in the acute drug treatment of migraine in children, crossover trials show lower placebo rates and higher therapeutic gain, compared with parallel group trials. This should be considered in the future design of acute drug trials in childhood migraine.

Entities: Chemical

Mesh：

Year: 2007 PMID： 17504653 DOI： 10.1007/s11916-007-0197-1

Source DB: PubMed Journal: Curr Pain Headache Rep ISSN： 1534-3081

17 in total

1. Intranasal sumatriptan for the acute treatment of migraine in children.

Authors: M A Ueberall; D Wenzel
Journal: Neurology Date: 1999-04-22 Impact factor: 9.910

2. A randomized trial of rizatriptan in migraine attacks in children.

Authors: K Ahonen; M L Hämäläinen; M Eerola; K Hoppu
Journal: Neurology Date: 2006-08-30 Impact factor: 9.910

3. Sumatriptan for migraine attacks in children: a randomized placebo-controlled study. Do children with migraine respond to oral sumatriptan differently from adults?

Authors: M L Hämäläinen; K Hoppu; P Santavuori
Journal: Neurology Date: 1997-04 Impact factor: 9.910

4. Treatment of childhood migraine attacks with oral zolmitriptan and ibuprofen.

Authors: S Evers; A Rahmann; C Kraemer; G Kurlemann; O Debus; I W Husstedt; A Frese
Journal: Neurology Date: 2006-06-14 Impact factor: 9.910

5. Rizatriptan 5 mg for the acute treatment of migraine in adolescents: a randomized, double-blind, placebo-controlled study.

Authors: Paul Winner; Donald Lewis; W Hester Visser; Kaihong Jiang; Suzanne Ahrens; Judith K Evans
Journal: Headache Date: 2002-01 Impact factor: 5.887

Review 6. Practice parameter: pharmacological treatment of migraine headache in children and adolescents: report of the American Academy of Neurology Quality Standards Subcommittee and the Practice Committee of the Child Neurology Society.

Authors: D Lewis; S Ashwal; A Hershey; D Hirtz; M Yonker; S Silberstein
Journal: Neurology Date: 2004-12-28 Impact factor: 9.910

7. Rizatriptan 5 mg for the acute treatment of migraine in adolescents: results from a double-blind, single-attack study and two open-label, multiple-attack studies.

Authors: W Hester Visser; Paul Winner; Kim Strohmaier; Meghan Klipfel; Yahong Peng; Kathleen McCarroll; Roger Cady; Donald Lewis; Robert Nett
Journal: Headache Date: 2004-10 Impact factor: 5.887

Controlled trials in pediatric migraine: crossover versus parallel group.

1. Intranasal sumatriptan for the acute treatment of migraine in children.

2. A randomized trial of rizatriptan in migraine attacks in children.

3. Sumatriptan for migraine attacks in children: a randomized placebo-controlled study. Do children with migraine respond to oral sumatriptan differently from adults?

4. Treatment of childhood migraine attacks with oral zolmitriptan and ibuprofen.

5. Rizatriptan 5 mg for the acute treatment of migraine in adolescents: a randomized, double-blind, placebo-controlled study.

Review 6. Practice parameter: pharmacological treatment of migraine headache in children and adolescents: report of the American Academy of Neurology Quality Standards Subcommittee and the Practice Committee of the Child Neurology Society.

7. Rizatriptan 5 mg for the acute treatment of migraine in adolescents: results from a double-blind, single-attack study and two open-label, multiple-attack studies.

8. Oral dihydroergotamine for therapy-resistant migraine attacks in children.

9. Children's ibuprofen suspension for the acute treatment of pediatric migraine.

Review 10. Placebo response in clinical randomized trials of analgesics in migraine.

1. Pain therapy in children and adolescents.

2. A Randomized Trial to Evaluate OnabotulinumtoxinA for Prevention of Headaches in Adolescents With Chronic Migraine.