| Literature DB >> 17504299 |
Augusto José Ferreira De Matos1, Célia Cristina Carreiras Lopes, Augusto Manuel Rodrigues Faustino, Júlio Gil Vale Carvalheira, Gerard Roel Rutteman, Maria De Fátima Rodrigues Moutinho Gärtner.
Abstract
Recent studies of canine malignant mammary tumours suggest that reduction of E-cadherin and/or beta-catenin correlates with invasive behaviour and lymph node metastasis. The aims of this study were to examine the interrelationships between the expression of E-cadherin and beta-catenin, and the relationship between the expression of E-cadherin and/or beta-catenin and the mode of growth and metastatic capacity of canine malignant mammary tumours. 90 spontaneous malignant tumours and local and regional lymph nodes were studied. A significant relationship was evidenced between membranous expression of E-cadherin and beta-catenin (p=0.0027), but not between E-cadherin and cytoplasmic beta-catenin. Only E-cadherin as a separate factor was significantly related to tumour invasion (p=0.0072) and lymph node metastasis (p=0.0001). Neither membranous nor cytoplasmic beta-catenin expression was significantly related to either of these phenomena.Entities:
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Year: 2007 PMID： 17504299 DOI： 10.1111/j.1600-0463.2007.apm_544.x
Source DB: PubMed Journal: APMIS ISSN： 0903-4641 Impact factor: 3.205