| Literature DB >> 17503837 |
Mariella Pattarozzi1, Cristiano Zonta, Quirinus B Broxterman, Bernard Kaptein, Rita De Zorzi, Lucio Randaccio, Paolo Scrimin, Giulia Licini.
Abstract
An efficient procedure for highly chemo- and stereoselective cyclization of (S)-allylalanine derivatives is reported (diastereomeric ratios up to 96:4) where the reaction course can be completely controlled by switching from gamma-lactones to cyclic carbamates simply with the proper choice of the amino acid protecting groups. Both processes are stereoconvergent and afford the (S,S)-products in high yields, short reaction times, and mild reaction conditions.Entities:
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Year: 2007 PMID： 17503837 DOI： 10.1021/ol070764k
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005