STUDY DESIGN: Brain wave activity in people with paraplegia, with and without neuropathic pain, was compared to brain wave activity in matched able-bodied controls. OBJECTIVES: To investigate whether spinal cord injury with neuropathic pain is associated with a slowing of brain wave activity. SETTING: Australia. METHODS: Electroencephalographic (EEG) data were collected in the eyes open (EO) and eyes closed (EC) states from 16 participants with paraplegia (eight with neuropathic pain and eight without pain) and matched able-bodied controls. Common EEG artefacts were removed using independent component analysis (ICA). Peak frequency in the theta-alpha band and EEG power in the delta, theta, alpha and beta frequency bands were compared between groups. RESULTS: The results show significant slowing of the EEG in people with neuropathic pain, consistent with the presence of thalamocortical dysrhythmia (TCD). Furthermore, people with neuropathic spinal cord injury (SCI) pain had significantly reduced EEG spectral reactivity in response to increased or decreased sensory input flowing into the thalamocortical network, as modulated by the eyes open and eyes closed states. CONCLUSION: The results provide further evidence for alterations in brain electric activity that may underlie the development of neuropathic pain following SCI.
STUDY DESIGN: Brain wave activity in people with paraplegia, with and without neuropathic pain, was compared to brain wave activity in matched able-bodied controls. OBJECTIVES: To investigate whether spinal cord injury with neuropathic pain is associated with a slowing of brain wave activity. SETTING: Australia. METHODS: Electroencephalographic (EEG) data were collected in the eyes open (EO) and eyes closed (EC) states from 16 participants with paraplegia (eight with neuropathic pain and eight without pain) and matched able-bodied controls. Common EEG artefacts were removed using independent component analysis (ICA). Peak frequency in the theta-alpha band and EEG power in the delta, theta, alpha and beta frequency bands were compared between groups. RESULTS: The results show significant slowing of the EEG in people with neuropathic pain, consistent with the presence of thalamocortical dysrhythmia (TCD). Furthermore, people with neuropathic spinal cord injury (SCI) pain had significantly reduced EEG spectral reactivity in response to increased or decreased sensory input flowing into the thalamocortical network, as modulated by the eyes open and eyes closed states. CONCLUSION: The results provide further evidence for alterations in brain electric activity that may underlie the development of neuropathic pain following SCI.
Authors: Francesco Di Russo; Alessandro Bultrini; Stefano Brunelli; Anna Sofia Delussu; Lorenzo Polidori; Francesco Taddei; Marco Traballesi; Donatella Spinelli Journal: J Neurotrauma Date: 2010-12 Impact factor: 5.269
Authors: Sam M Doesburg; Urs Ribary; Anthony T Herdman; Alexander Moiseev; Teresa Cheung; Steven P Miller; Kenneth J Poskitt; Hal Weinberg; Michael F Whitfield; Anne Synnes; Ruth E Grunau Journal: Pediatr Res Date: 2011-08 Impact factor: 3.756
Authors: Juan Aguilar; Desiré Humanes-Valera; Elena Alonso-Calviño; Josué G Yague; Karen A Moxon; Antonio Oliviero; Guglielmo Foffani Journal: J Neurosci Date: 2010-06-02 Impact factor: 6.167
Authors: Rifqi O Affan; Siyuan Huang; Stephen M Cruz; Lee A Holcomb; Edward Nguyen; Ksenija Marinkovic Journal: Alcohol Date: 2018-01-08 Impact factor: 2.405
Authors: Flavia Di Pietro; Paul M Macey; Caroline D Rae; Zeynab Alshelh; Vaughan G Macefield; E Russell Vickers; Luke A Henderson Journal: Hum Brain Mapp Date: 2018-01-17 Impact factor: 5.038