Literature DB >> 17502410

Lack of an effect of antibiotic treatment on prolonged detection of chlamydial DNA in murine genital tract infection.

Dawn M Reeves1, Uma Nagarajan, Catherine O'Connell, Charles W Andrews, Toni Darville.   

Abstract

Mice treated with antibiotics early or late after active infection had resolved were examined for chlamydial DNA in endocervical swabs. The early eradication of infection limited oviduct pathology, despite the continued detection of chlamydial DNA by nested PCR. Late antibiotic treatment had no effect on the ability to detect DNA or oviduct pathology.

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Year:  2007        PMID： 17502410      PMCID： PMC1913253          DOI： 10.1128/AAC.00231-07

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  9 in total

1.  Chlamydia trachomatis persistence in the female mouse genital tract: inducible nitric oxide synthase and infection outcome.

Authors:  K H Ramsey; G S Miranpuri; I M Sigar; S Ouellette; G I Byrne
Journal:  Infect Immun       Date:  2001-08       Impact factor: 3.441

2.  The natural course of Chlamydia trachomatis infection in asymptomatic Colombian women: a 5-year follow-up study.

Authors:  Monica Molano; Chris J L M Meijer; Elisabete Weiderpass; Annie Arslan; Hector Posso; Silvia Franceschi; Margarita Ronderos; Nubia Muñoz; Adriaan J C van den Brule
Journal:  J Infect Dis       Date:  2005-02-09       Impact factor: 5.226

3.  Effects of doxycycline and antiinflammatory agents on experimentally induced chlamydial upper genital tract infection in female macaques.

Authors:  D L Patton; Y C Sweeney; N J Bohannon; A M Clark; J P Hughes; A Cappuccio; L A Campbell; W E Stamm
Journal:  J Infect Dis       Date:  1997-03       Impact factor: 5.226

4.  Mouse strain-dependent variation in the course and outcome of chlamydial genital tract infection is associated with differences in host response.

Authors:  T Darville; C W Andrews; K K Laffoon; W Shymasani; L R Kishen; R G Rank
Journal:  Infect Immun       Date:  1997-08       Impact factor: 3.441

5.  The infecting dose of Chlamydia muridarum modulates the innate immune response and ascending infection.

Authors:  Heather K Maxion; Wei Liu; Mi-Hyang Chang; Kathleen A Kelly
Journal:  Infect Immun       Date:  2004-11       Impact factor: 3.441

6.  The effect of doxycycline treatment on the development of protective immunity in a murine model of chlamydial genital infection.

Authors:  H Su; R Morrison; R Messer; W Whitmire; S Hughes; H D Caldwell
Journal:  J Infect Dis       Date:  1999-10       Impact factor: 5.226

7.  Initial route of antigen administration alters the T-cell cytokine profile produced in response to the mouse pneumonitis biovar of Chlamydia trachomatis following genital infection.

Authors:  K A Kelly; E A Robinson; R G Rank
Journal:  Infect Immun       Date:  1996-12       Impact factor: 3.441

8.  The plasmids of Chlamydia trachomatis and Chlamydophila pneumoniae (N16): accurate determination of copy number and the paradoxical effect of plasmid-curing agents.

Authors:  Mark A Pickett; J Sylvia Everson; Patrick J Pead; Ian N Clarke
Journal:  Microbiology (Reading)       Date:  2005-03       Impact factor: 2.777

9.  Long-term eradication of Chlamydia trachomatis genital infection after antimicrobial therapy. Evidence against persistent infection.

Authors:  K A Workowski; M F Lampe; K G Wong; M B Watts; W E Stamm
Journal:  JAMA       Date:  1993-11-03       Impact factor: 56.272
  9 in total
  1 in total

1.  PmpG303-311, a protective vaccine epitope that elicits persistent cellular immune responses in Chlamydia muridarum-immune mice.

Authors:  Raymond M Johnson; Hong Yu; Micah S Kerr; James E Slaven; Karuna P Karunakaran; Robert C Brunham
Journal:  Infect Immun       Date:  2012-03-19       Impact factor: 3.441
  1 in total

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