Literature DB >> 17502225

Role of tight junctions in cell proliferation and cancer.

Lorenza González-Mariscal1, Susana Lechuga, Erika Garay.   

Abstract

The acquisition of a cancerous phenotype by epithelial cells involves the disruption of intercellular adhesions. The reorganization of the E-cadherin/beta-catenin complex in adherens junctions during cell transformation is widely recognized. Instead the implication of tight junctions (TJs) in this process is starting to be unraveled. The aim of this article is to review the role of TJ proteins in cell proliferation and cancer.

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Year:  2007        PMID： 17502225     DOI： 10.1016/j.proghi.2007.01.001

Source DB:  PubMed          Journal:  Prog Histochem Cytochem        ISSN： 0079-6336


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