| Literature DB >> 17502138 |
Kazuki Matsui1, Yoshihiro Sasaki, Takayoshi Komatsu, Masaru Mukai, Jun-ichi Kikuchi, Yasuhiro Aoyama.
Abstract
Surface-rigidified cerasomes (ceramic-coated liposomes) are neither fused nor cross-linked when bound to siRNA (short duplex RNA) but not to plasmid DNA (long duplex DNA) which induces cross-linking. Non-ceramic reference liposomes are easily fused by the siRNA. The cerasome can thus be used as a viral-size siRNA-carrier in a wide range of concentration for RNAi silencing of exogenous and endogenous genes.Entities:
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Year: 2007 PMID： 17502138 DOI： 10.1016/j.bmcl.2007.04.097
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823