Literature DB >> 17499882

Altered anxiety-related behavior in nociceptin/orphanin FQ receptor gene knockout mice.

Elaine C Gavioli1, Anna Rizzi, Giuliano Marzola, Silvia Zucchini, Domenico Regoli, Girolamo Calo'.   

Abstract

Studies showed that nociceptin/orphanin FQ (N/OFQ) peptide receptor (NOP) agonists produce anxiolytic-like actions, while little is known about the effects of blockade of NOP receptor signaling in anxiety. To this aim, we investigated the behavioral phenotype of NOP receptor gene knockout mice (NOP(-/-)) in different assays. In the elevated plus-maze and light-dark box, NOP(-/-) mice displayed increased anxiety-related behavior. In the novelty-suppressed feeding behavior and elevated T-maze, NOP(-/-) mice showed anxiolytic-like phenotype, while no differences were found in the open-field, hole-board, marble-burying, and stress-induced hyperthermia. Altogether, these findings suggest that the N/OFQ-NOP receptor system modulates anxiety-related behavior in a complex manner.

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Year:  2007        PMID： 17499882     DOI： 10.1016/j.peptides.2007.04.012

Source DB:  PubMed          Journal:  Peptides        ISSN： 0196-9781            Impact factor:   3.750


  22 in total

Review 1.  Functional plasticity of the N/OFQ-NOP receptor system determines analgesic properties of NOP receptor agonists.

Authors:  W Schröder; D G Lambert; M C Ko; T Koch
Journal:  Br J Pharmacol       Date:  2014-08       Impact factor: 8.739

Review 2.  A critical inquiry into marble-burying as a preclinical screening paradigm of relevance for anxiety and obsessive-compulsive disorder: Mapping the way forward.

Authors:  Geoffrey de Brouwer; Arina Fick; Brian H Harvey; De Wet Wolmarans
Journal:  Cogn Affect Behav Neurosci       Date:  2019-02       Impact factor: 3.282

3.  Further characterization of the prototypical nociceptin/orphanin FQ peptide receptor agonist Ro 64-6198 in rodent models of conflict anxiety and despair.

Authors:  Celia Goeldner; Will Spooren; Jürgen Wichmann; Eric P Prinssen
Journal:  Psychopharmacology (Berl)       Date:  2012-01-18       Impact factor: 4.530

Review 4.  The genetics of the opioid system and specific drug addictions.

Authors:  Orna Levran; Vadim Yuferov; Mary Jeanne Kreek
Journal:  Hum Genet       Date:  2012-05-01       Impact factor: 4.132

Review 5.  Targeting opioid dysregulation in depression for the development of novel therapeutics.

Authors:  Caroline A Browne; Irwin Lucki
Journal:  Pharmacol Ther       Date:  2019-04-30       Impact factor: 12.310

6.  Endogenous nociceptin/orphanin-FQ in the dorsal hippocampus facilitates despair-related behavior.

Authors:  Celia Goeldner; David Reiss; Brigitte L Kieffer; Abdel-Mouttalib Ouagazzal
Journal:  Hippocampus       Date:  2010-08       Impact factor: 3.899

7.  Neuropeptidergic signaling partitions arousal behaviors in zebrafish.

Authors:  Ian G Woods; David Schoppik; Veronica J Shi; Steven Zimmerman; Haley A Coleman; Joel Greenwood; Edward R Soucy; Alexander F Schier
Journal:  J Neurosci       Date:  2014-02-26       Impact factor: 6.167

Review 8.  50 years of hurdles and hope in anxiolytic drug discovery.

Authors:  Guy Griebel; Andrew Holmes
Journal:  Nat Rev Drug Discov       Date:  2013-09       Impact factor: 84.694

9.  Genetic and pharmacological evidence that endogenous nociceptin/orphanin FQ contributes to dopamine cell loss in Parkinson's disease.

Authors:  Ludovico Arcuri; Riccardo Viaro; Simone Bido; Francesco Longo; Mariangela Calcagno; Pierre-Olivier Fernagut; Nurulain T Zaveri; Girolamo Calò; Erwan Bezard; Michele Morari
Journal:  Neurobiol Dis       Date:  2016-01-22       Impact factor: 5.996

Review 10.  The Nociceptin Receptor as an Emerging Molecular Target for Cocaine Addiction.

Authors:  Kabirullah Lutfy; Nurulain T Zaveri
Journal:  Prog Mol Biol Transl Sci       Date:  2015-12-23       Impact factor: 3.622
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