| Literature DB >> 17499610 |
Reiko Nagasaka1, Chatchawan Chotimarkorn, Islam Md Shafiqul, Masatoshi Hori, Hiroshi Ozaki, Hideki Ushio.
Abstract
NF-kappaB family of transcription factors are involved in numerous cellular processes, including differentiation, proliferation, and inflammation. It was reported that hydroxycinnamic acid derivatives (HADs) are inhibitors of NF-kappaB activation. Rice bran oil contains a lot of phytosteryl ferulates, one of HADs. We have investigated effects of phytosteryl ferulates on NF-kappaB activation in macrophage. Cycloartenyl ferulate (CAF), one of phytosteryl ferulates, significantly reduced lipopolysaccharide (LPS)-induced NO production and mRNA expression of inducible NO synthase and cyclooxygenese-2 but upregulated SOD activity. Electrophoresis mobility shift assay revealed that CAF inhibited DNA-binding of NF-kappaB. CAF and phytosteryl ferulates probably have potentially anti-inflammatory properties.Entities:
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Year: 2007 PMID： 17499610 DOI： 10.1016/j.bbrc.2007.04.178
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575