| Literature DB >> 17499399 |
Miranda E A T van Berkel1, Elise H R Schrijver, Andries van Mourik, Kiki Tesselaar, Peter van der Ley, Liana Steeghs, Mariëtte A Oosterwegel.
Abstract
The development of novel vaccines against Neisseria meningitidis recently gained momentum by the generation of penta-acylated lpxL1 LPS which has similar adjuvant activity, but reduced endotoxic activity as compared to hexa-acylated wild type (H44/76) LPS. We investigated the costimulation requirements for the adjuvant activity of both forms of LPS by immunizing CD28-, ICOS- and B7.1/2/ICOS-deficient mice. Both ICOS and CD28 appeared essential for optimal adjuvant activity of H44/76 LPS or lpxL1 LPS. Interestingly, ICOS-mediated costimulation predominates in the adjuvant activity of lpxL1 LPS, while both ICOS and CD28 are required for H44/76 LPS adjuvant activity.Entities:
Mesh：
Substances：
Year: 2007 PMID： 17499399 DOI： 10.1016/j.vaccine.2007.04.016
Source DB: PubMed Journal: Vaccine ISSN： 0264-410X Impact factor: 3.641