Literature DB >> 17499155

Stable isotope pilot study of exchangeable copper kinetics in human blood plasma.

Tony I Venelinov1, John H Beattie, Jack R Dainty, Wendy J Hollands, Susan J Fairweather-Tait, Linda J Harvey.   

Abstract

To develop further our understanding of initial dietary copper metabolism, a method has been developed to separate plasma copper that is bound to albumin, from that bound to ceruloplasmin. This method has been tested using plasma samples from a pilot study involving six human volunteers who consumed 3mg oral doses of the stable isotope (65)Cu and gave blood samples at timed intervals up to 7 days. The results suggest that this method can be used to monitor dynamic fluctuations in newly absorbed copper over a short time frame.

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Year:  2007        PMID: 17499155     DOI: 10.1016/j.jtemb.2007.01.001

Source DB:  PubMed          Journal:  J Trace Elem Med Biol        ISSN: 0946-672X            Impact factor:   3.849


  2 in total

Review 1.  New tools for Wilson's disease diagnosis: exchangeable copper fraction.

Authors:  France Woimant; Nouzha Djebrani-Oussedik; Aurélia Poujois
Journal:  Ann Transl Med       Date:  2019-04

2.  Evolution of exchangeable copper and relative exchangeable copper through the course of Wilson's disease in the Long Evans Cinnamon rat.

Authors:  Françoise Schmitt; Guillaume Podevin; Joël Poupon; Jérôme Roux; Pierre Legras; Jean-Marc Trocello; France Woimant; Olivier Laprévote; Tuan Huy Nguyen; Souleiman El Balkhi
Journal:  PLoS One       Date:  2013-12-17       Impact factor: 3.240

  2 in total

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