| Literature DB >> 17498953 |
Olivier Roche1, Rosa María Rodríguez Sarmiento.
Abstract
Design and synthesis of highly potent and selective non-imidazole inverse agonists for the histamine H(3) receptor is described. The study validates a new pharmacophore model based on the merging of two previously described models. It also demonstrates that the removal of the basic center potentially interacting with ASP3.32 and common to both models leads to loss of activity, whereas the replacement of the second basic center by an acceptor retains the potency.Entities:
Mesh：
Substances：
Year: 2007 PMID： 17498953 DOI： 10.1016/j.bmcl.2007.04.056
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823