Literature DB >> 17498949

Liver X receptor antagonists with a phthalimide skeleton derived from thalidomide-related glucosidase inhibitors.

Tomomi Noguchi-Yachide1, Atsushi Aoyama, Makoto Makishima, Hiroyuki Miyachi, Yuichi Hashimoto.   

Abstract

Alpha-glucosidase inhibitors with a chlorinated phthalimide or a thiophthalimide skeleton, derived from thalidomide, were found to possess liver X receptor (LXR) antagonistic activity. Novel LXR antagonists with a 2'-substituted phenylphthalimide skeleton were obtained by structural development of glucosidase inhibitors derived from thalidomide.

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Year:  2007        PMID： 17498949     DOI： 10.1016/j.bmcl.2007.04.090

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  4 in total

1.  Borylated 2,3,4,5-Tetrachlorophthalimide and Their 2,3,4,5-Tetrachlorobenzamide Analogues: Synthesis, Their Glycosidase Inhibition and Anticancer Properties in View to Boron Neutron Capture Therapy.

Authors:  David M Campkin; Yuna Shimadate; Barbara Bartholomew; Paul V Bernhardt; Robert J Nash; Jennette A Sakoff; Atsushi Kato; Michela I Simone
Journal:  Molecules       Date:  2022-05-26       Impact factor: 4.927

2.  Styrylphenylphthalimides as Novel Transrepression-Selective Liver X Receptor (LXR) Modulators.

Authors:  Sayaka Nomura; Kaori Endo-Umeda; Atsushi Aoyama; Makoto Makishima; Yuichi Hashimoto; Minoru Ishikawa
Journal:  ACS Med Chem Lett       Date:  2015-07-13       Impact factor: 4.345

3.  2-[4-tert-Butyl-5-(2-chloro-benz-yl)-1,3-thia-zol-2-yl]isoindoline-1,3-dione.

Authors:  Zhi-Gang Yao; Jun-Mei Peng; Su-Fang Huo; Ai-Xi Hu
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-10-23

Review 4.  Influence of Altered Thyroid Hormone Mechanisms in the Progression of Metabolic Dysfunction Associated with Fatty Liver Disease (MAFLD): A Systematic Review.

Authors:  Rafael Aguiar Marschner; Fernanda Arenhardt; Rafael Teixeira Ribeiro; Simone Magagnin Wajner
Journal:  Metabolites       Date:  2022-07-22
  4 in total

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