BACKGROUND & AIMS: Osteoporosis is a major health problem worldwide. Low weight is a major risk factor for low bone mass and fractures. The aim of this study was to investigate the effects on bone tissue of protein-rich supplementation alone or in combination with nandrolone decanoate in lean elderly women after a hip fracture. METHODS:Sixty elderly women with BMI <24 kg/m(2) admitted to hospital due to a femoral neck fracture were randomised to a control group, to receive a protein-rich formula or to receive the same formula with an addition of nandrolone decanoate for 6 months. All patients received additional calcium and vitamin D. The effects after 6 and 12 months were measured by means of bone mineral density (BMD) using dual-energy X-ray absorptiometry (DXA), and with biochemical bone markers. Osteocalcin and C-terminal telopeptide of collagen-1 (CTX) were used to estimate bone formation and bone resorption, respectively. RESULTS: The analyses showed an increase in total body BMD at 6 and 12 months in patients who received protein-rich supplementation. Nandrolone decanoate did not appear to have any additional effect on BMD. Osteocalcin increased in all groups while no significant changes were found for CTX. CONCLUSION: The overall results of the study indicated that protein-rich supplementation given to lean elderly female hip fracture patients increased the total body BMD.
RCT Entities:
BACKGROUND & AIMS:Osteoporosis is a major health problem worldwide. Low weight is a major risk factor for low bone mass and fractures. The aim of this study was to investigate the effects on bone tissue of protein-rich supplementation alone or in combination with nandrolone decanoate in lean elderly women after a hip fracture. METHODS: Sixty elderly women with BMI <24 kg/m(2) admitted to hospital due to a femoral neck fracture were randomised to a control group, to receive a protein-rich formula or to receive the same formula with an addition of nandrolone decanoate for 6 months. All patients received additional calcium and vitamin D. The effects after 6 and 12 months were measured by means of bone mineral density (BMD) using dual-energy X-ray absorptiometry (DXA), and with biochemical bone markers. Osteocalcin and C-terminal telopeptide of collagen-1 (CTX) were used to estimate bone formation and bone resorption, respectively. RESULTS: The analyses showed an increase in total body BMD at 6 and 12 months in patients who received protein-rich supplementation. Nandrolone decanoate did not appear to have any additional effect on BMD. Osteocalcin increased in all groups while no significant changes were found for CTX. CONCLUSION: The overall results of the study indicated that protein-rich supplementation given to lean elderly female hip fracturepatients increased the total body BMD.
Authors: D Pinto; M Alshahrani; R Chapurlat; T Chevalley; E Dennison; B M Camargos; A Papaioannou; S Silverman; J-F Kaux; N E Lane; J Morales Torres; J Paccou; R Rizzoli; O Bruyere Journal: Osteoporos Int Date: 2022-01-20 Impact factor: 4.507
Authors: Lena Flodin; Maria Sääf; Tommy Cederholm; Amer N Al-Ani; Paul W Ackermann; Eva Samnegård; Nils Dalen; Margareta Hedström Journal: Clin Interv Aging Date: 2014-07-07 Impact factor: 4.458
Authors: Riccardo Calvani; Anna Maria Martone; Emanuele Marzetti; Graziano Onder; Giulia Savera; Maria Lorenzi; Elisabetta Serafini; Roberto Bernabei; Francesco Landi Journal: Front Aging Neurosci Date: 2014-11-19 Impact factor: 5.750