OBJECTIVE: To determine the association between findings on review of preoperative biopsy specimens and the risk of lymph node involvement (LNI) at radical hysterectomy in patients with early-stage cervical cancer. METHODS: Eighty-one patients were included in this retrospective review. Preoperative biopsy features evaluated were stage, grade, histologic subtype, lymph-vascular space invasion (LVSI), and depth (>4 mm) of invasion. RESULTS: Twelve patients (14.8%) had LNI at radical hysterectomy. Stage, grade, and histologic subtype were not associated with LNI. LVSI and depth of invasion >4 mm were both significantly associated with LNI (25.6% vs. 4.8%, P=0.01, and 25.0% vs. 4.5%, P=0.01, respectively). LVSI with >4 mm invasion was 6.6 times more likely to have LNI at the time of radical hysterectomy (RR=6.6; 95% confidence interval, 2.1-21.9). CONCLUSION: Patients with preoperative LVSI are at higher risk for LNI at radical hysterectomy and should be counseled regarding potential implications for management.
OBJECTIVE: To determine the association between findings on review of preoperative biopsy specimens and the risk of lymph node involvement (LNI) at radical hysterectomy in patients with early-stage cervical cancer. METHODS: Eighty-one patients were included in this retrospective review. Preoperative biopsy features evaluated were stage, grade, histologic subtype, lymph-vascular space invasion (LVSI), and depth (>4 mm) of invasion. RESULTS: Twelve patients (14.8%) had LNI at radical hysterectomy. Stage, grade, and histologic subtype were not associated with LNI. LVSI and depth of invasion >4 mm were both significantly associated with LNI (25.6% vs. 4.8%, P=0.01, and 25.0% vs. 4.5%, P=0.01, respectively). LVSI with >4 mm invasion was 6.6 times more likely to have LNI at the time of radical hysterectomy (RR=6.6; 95% confidence interval, 2.1-21.9). CONCLUSION:Patients with preoperative LVSI are at higher risk for LNI at radical hysterectomy and should be counseled regarding potential implications for management.
Authors: Ricardo dos Reis; Jennifer K Burzawa; Audrey T Tsunoda; Masayoshi Hosaka; Michael Frumovitz; Shannon N Westin; Mark F Munsell; Pedro T Ramirez Journal: Int J Gynecol Cancer Date: 2015-09 Impact factor: 3.437
Authors: Mieke L G Ten Eikelder; Floor Hinten; Anke Smits; Maaike A Van der Aa; Ruud L M Bekkers; Joanna IntHout; Hans H B Wenzel; Petra L M Zusterzeel Journal: Cancers (Basel) Date: 2022-06-27 Impact factor: 6.575
Authors: K Matsuo; S Mabuchi; M Okazawa; Y Matsumoto; T Tsutsui; M Fujita; S Kamiura; K Ogawa; C P Morrow; T Kimura Journal: Br J Cancer Date: 2013-03-05 Impact factor: 7.640