BACKGROUND: Mild steatosis has been thought not to affect outcome after liver resection. However, recent studies have reported impaired postoperative recovery of patients with mild steatosis. This study evaluated the recovery of hepatic functional reserve during regeneration in a rat model of mild steatosis and liver resection. METHODS: Male Wistar rats had a standard methione- and choline-deficient diet to induce mild steatosis before 70 per cent liver resection. Evaluation of hepatobiliary function was by (99m)Tc-labelled mebrofenin scintigraphy. Mebrofenin uptake rate, the time for maximum uptake (T peak) and the time required for peak activity to decrease by 50 per cent (T(1/2) peak) were assessed 1, 2, 3 and 7 days after liver resection, along with regeneration of the remnant liver, hepatocellular and sinusoidal damage, and hepatic adenosine 5'-triphosphate (ATP) levels. RESULTS: Liver regeneration and proliferative response in mild steatotic rats were no different from those in controls. However, the mebrofenin uptake rate was lower (P < 0.050) and the recovery of hepatic ATP impaired (P < 0.050) in animals with mild steatosis. Hepatocellular damage was increased (P < 0.050) but sinusoidal endothelial cell function was not affected after liver resection in mildly steatotic rats. CONCLUSION: Mild steatosis impaired functional recovery and increased hepatocellular damage after liver resection. Copyright (c) 2007 British Journal of Surgery Society Ltd.
BACKGROUND: Mild steatosis has been thought not to affect outcome after liver resection. However, recent studies have reported impaired postoperative recovery of patients with mild steatosis. This study evaluated the recovery of hepatic functional reserve during regeneration in a rat model of mild steatosis and liver resection. METHODS: Male Wistar rats had a standard methione- and choline-deficient diet to induce mild steatosis before 70 per cent liver resection. Evaluation of hepatobiliary function was by (99m)Tc-labelled mebrofenin scintigraphy. Mebrofenin uptake rate, the time for maximum uptake (T peak) and the time required for peak activity to decrease by 50 per cent (T(1/2) peak) were assessed 1, 2, 3 and 7 days after liver resection, along with regeneration of the remnant liver, hepatocellular and sinusoidal damage, and hepatic adenosine 5'-triphosphate (ATP) levels. RESULTS: Liver regeneration and proliferative response in mild steatotic rats were no different from those in controls. However, the mebrofenin uptake rate was lower (P < 0.050) and the recovery of hepatic ATP impaired (P < 0.050) in animals with mild steatosis. Hepatocellular damage was increased (P < 0.050) but sinusoidal endothelial cell function was not affected after liver resection in mildly steatotic rats. CONCLUSION: Mild steatosis impaired functional recovery and increased hepatocellular damage after liver resection. Copyright (c) 2007 British Journal of Surgery Society Ltd.
Authors: Amit K Mathur; Amir A Ghaferi; Kristen Sell; Christopher J Sonnenday; Michael J Englesbe; Theodore H Welling Journal: J Gastrointest Surg Date: 2010-02-06 Impact factor: 3.452
Authors: Nele Boeykens; Peter Ponsaerts; Annemie Van der Linden; Zwi Berneman; Dirk Ysebaert; Kathleen De Greef Journal: PLoS One Date: 2013-07-18 Impact factor: 3.240
Authors: Damian J Mole; Jonathan A Fallowfield; Timothy J Kendall; Fenella Welsh; Scott I Semple; Velicia Bachtiar; Matt Kelly; Stephen J Wigmore; O James Garden; Henry R Wilman; Rajarshi Banerjee; Myrddin Rees; Michael Brady Journal: BMC Cancer Date: 2018-09-12 Impact factor: 4.430
Authors: Siavash Raigani; Negin Karimian; Viola Huang; Anna M Zhang; Irene Beijert; Sharon Geerts; Sonal Nagpal; Ehab O A Hafiz; Fermin M Fontan; Mohamed M Aburawi; Paria Mahboub; James F Markmann; Robert J Porte; Korkut Uygun; Martin Yarmush; Heidi Yeh Journal: PLoS One Date: 2020-01-24 Impact factor: 3.240