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Literature DB >> 17497204

Anti-inflammation role for mesenchymal stem cells transplantation in myocardial infarction.

Jun Guo¹, Guo-sheng Lin, Cui-yu Bao, Zhi-min Hu, Ming-yan Hu.

Abstract

The aim of the present study was to investigate the role of anti-inflammation for MSCs transplantation in rat models of myocardial infarction. Rats with AMI induced by occlusion of the left coronary artery were randomized to MSCs transplantation group, MI group and sham operated group. The effects of MSCs transplantation on cardiac inflammation and left ventricular remodeling in non-infarcted zone were observed after 4 weeks of MI. We found that MSC transplantation (1) decreased protein production and gene expression of inflammation cytokines TNF-alpha, IL-1beta and IL-6, (2) inhibited deposition of type I and III collagen, as well as gene and protein expression of MMP-1 and TIMP-1, (3) attenuated LV cavitary dilation and transmural infarct thinning, thus prevent myocardial remodeling after myocardial infarction, and (4) increased EF, FS, LVESP and dp/dtmax (P < 0.01), decreased LVDd, LVEDV, LVEDP (P < 0.05). Anti-inflammation role for MSCs transplantation might partly account for the cardiac protective effect in ischemic heart disease.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2007 PMID： 17497204 DOI： 10.1007/s10753-007-9025-3

Source DB: PubMed Journal: Inflammation ISSN： 0360-3997 Impact factor: 4.092

30 in total

1. Transplantation of embryonic stem cells improves cardiac function in postinfarcted rats.

Authors: Jiang-Yong Min; Yinke Yang; Kimber L Converso; Lixin Liu; Qin Huang; James P Morgan; Yong-Fu Xiao
Journal: J Appl Physiol (1985) Date: 2002-01

2. Comparison of the effects of fetal cardiomyocyte and skeletal myoblast transplantation on postinfarction left ventricular function.

Authors: M Scorsin; A Hagège; J T Vilquin; M Fiszman; F Marotte; J L Samuel; L Rappaport; K Schwartz; P Menasché
Journal: J Thorac Cardiovasc Surg Date: 2000-06 Impact factor: 5.209

Review 3. Mesenchymal stem cells: clinical applications and biological characterization.

Authors: Frank P Barry; J Mary Murphy
Journal: Int J Biochem Cell Biol Date: 2004-04 Impact factor: 5.085

4. Altered cardiac collagen and associated changes in diastolic function of infarcted rat hearts.

Authors: R Van Kerckhoven; E A Kalkman; P R Saxena; R G Schoemaker
Journal: Cardiovasc Res Date: 2000-05 Impact factor: 10.787

5. Evolution of matrix metalloprotease and tissue inhibitor expression during heart failure progression in the infarcted rat.

Authors: J T Peterson; H Li; L Dillon; J W Bryant
Journal: Cardiovasc Res Date: 2000-05 Impact factor: 10.787

6. Transplantation of mesenchymal stem cells from human bone marrow improves damaged heart function in rats.

Authors: Mai Hou; Ke-ming Yang; Hao Zhang; Wei-Quan Zhu; Fu-jian Duan; Hao Wang; Yun-hu Song; Ying-jie Wei; Sheng-shou Hu
Journal: Int J Cardiol Date: 2006-08-04 Impact factor: 4.164

7. Selective down-regulation of extracellular matrix gene expression by bone marrow derived stem cell transplantation into infarcted myocardium.

Authors: Xiaohua Xu; Zenglu Xu; Yuanyuan Xu; Guanghui Cui
Journal: Circ J Date: 2005-10 Impact factor: 2.993

8. Bone marrow stem cells prevent left ventricular remodeling of ischemic heart through paracrine signaling.

Authors: Ryota Uemura; Meifeng Xu; Nauman Ahmad; Muhammad Ashraf
Journal: Circ Res Date: 2006-05-11 Impact factor: 17.367

9. Long-term improvement of cardiac function in rats after infarction by transplantation of embryonic stem cells.

Authors: Jiang-Yong Min; Yinke Yang; Matthew F Sullivan; Qingen Ke; Kimber L Converso; Yu Chen; James P Morgan; Yong-Fu Xiao
Journal: J Thorac Cardiovasc Surg Date: 2003-02 Impact factor: 5.209

10. Regenerating functional myocardium: improved performance after skeletal myoblast transplantation.

Authors: D A Taylor; B Z Atkins; P Hungspreugs; T R Jones; M C Reedy; K A Hutcheson; D D Glower; W E Kraus
Journal: Nat Med Date: 1998-08 Impact factor: 53.440

48 in total

1. Effect of disruption of Akt-1 of lin(-)c-kit(+) stem cells on myocardial performance in infarcted heart.

Authors: Andy Tseng; Joan Stabila; Beth McGonnigal; Naohiro Yano; Mao-Jing Yang; Yi-Tang Tseng; Pamela A Davol; Lawrence G Lum; James F Padbury; Ting C Zhao
Journal: Cardiovasc Res Date: 2010-04-21 Impact factor: 10.787

Review 2. Effects of neuroinflammation on the regenerative capacity of brain stem cells.

Authors: Isabella Russo; Sergio Barlati; Francesca Bosetti
Journal: J Neurochem Date: 2011-01-19 Impact factor: 5.372

Review 3. Paracrine mechanisms of stem cell reparative and regenerative actions in the heart.

Authors: Maria Mirotsou; Tilanthi M Jayawardena; Jeffrey Schmeckpeper; Massimiliano Gnecchi; Victor J Dzau
Journal: J Mol Cell Cardiol Date: 2010-08-19 Impact factor: 5.000

4. Functions of Mesenchymal Stem Cells in Cardiac Repair.

Authors: Selçuk Öztürk; Ayşe Eser Elçin; Yaşar Murat Elçin
Journal: Adv Exp Med Biol Date: 2021 Impact factor: 2.622

5. Anti-inflammatory Activity of Mesenchymal Stem Cells in λ-Carrageenan-Induced Chronic Inflammation in Rats: Reactions of the Blood System, Leukocyte-Monocyte Ratio.

Authors: Nataliia Petryk; Oleksandr Shevchenko
Journal: Inflammation Date: 2020-10 Impact factor: 4.092

6. Cell contact, prostaglandin E(2) and transforming growth factor beta 1 play non-redundant roles in human mesenchymal stem cell induction of CD4+CD25(High) forkhead box P3+ regulatory T cells.

Authors: K English; J M Ryan; L Tobin; M J Murphy; F P Barry; B P Mahon
Journal: Clin Exp Immunol Date: 2009-02-03 Impact factor: 4.330