| Literature DB >> 17497106 |
Dagmar Hartung1, Michael Schäfers, Shinichiro Fujimoto, Bodo Levkau, Navneet Narula, Klaus Kopka, Renu Virmani, Chris Reutelingsperger, Leo Hofstra, Frank D Kolodgie, Artiom Petrov, Jagat Narula.
Abstract
INTRODUCTION: Inflammation plays an important role in vulnerability of atherosclerotic plaques to rupture and hence acute coronary events. The monocyte-macrophage infiltration in plaques leads to upregulation of cytokines and metalloproteinase enzymes. Matrix metalloproteinases result in matrix dissolution and consequently expansive remodeling of the vessel. They also contribute to attenuation of fibrous cap and hence susceptibility to rupture. Assessment of metalloproteinase expression and activity should provide information about plaque instability.Entities:
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Year: 2007 PMID： 17497106 DOI： 10.1007/s00259-007-0435-0
Source DB: PubMed Journal: Eur J Nucl Med Mol Imaging ISSN： 1619-7070 Impact factor: 9.236