Literature DB >> 17496198

Insulin-degrading enzyme is genetically associated with Alzheimer's disease in the Finnish population.

Saila Vepsäläinen, Michele Parkinson, Seppo Helisalmi, Arto Mannermaa, Hilkka Soininen, Rudolph E Tanzi, Lars Bertram, Mikko Hiltunen.   

Abstract

The gene for insulin-degrading enzyme (IDE), which is located at chromosome 10q24, has been previously proposed as a candidate gene for late-onset Alzheimer's disease (AD) based on its ability to degrade amyloid beta-protein. Genotyping of single nucleotide polymorphisms (SNPs) in the IDE gene in Finnish patients with AD and controls revealed SNPs rs4646953 and rs4646955 to be associated with AD, conferring an approximately two-fold increased risk. Single locus findings were corroborated by the results obtained from haplotype analyses. This suggests that genetic alterations in or near the IDE gene may increase the risk for developing AD.

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Year:  2007        PMID： 17496198      PMCID： PMC2597950          DOI： 10.1136/jmg.2006.048470

Source DB:  PubMed          Journal:  J Med Genet        ISSN： 0022-2593            Impact factor:   6.318


  9 in total

1.  Evidence for genetic linkage of Alzheimer's disease to chromosome 10q.

Authors:  L Bertram; D Blacker; K Mullin; D Keeney; J Jones; S Basu; S Yhu; M G McInnis; R C Go; K Vekrellis; D J Selkoe; A J Saunders; R E Tanzi
Journal:  Science       Date:  2000-12-22       Impact factor: 47.728

2.  Susceptibility locus for Alzheimer's disease on chromosome 10.

Authors:  A Myers; P Holmans; H Marshall; J Kwon; D Meyer; D Ramic; S Shears; J Booth; F W DeVrieze; R Crook; M Hamshere; R Abraham; N Tunstall; F Rice; S Carty; S Lillystone; P Kehoe; V Rudrasingham; L Jones; S Lovestone; J Perez-Tur; J Williams; M J Owen; J Hardy; A M Goate
Journal:  Science       Date:  2000-12-22       Impact factor: 47.728

3.  Linkage of plasma Abeta42 to a quantitative locus on chromosome 10 in late-onset Alzheimer's disease pedigrees.

Authors:  N Ertekin-Taner; N Graff-Radford; L H Younkin; C Eckman; M Baker; J Adamson; J Ronald; J Blangero; M Hutton; S G Younkin
Journal:  Science       Date:  2000-12-22       Impact factor: 47.728

4.  Genetic variation in a haplotype block spanning IDE influences Alzheimer disease.

Authors:  Jonathan A Prince; Lars Feuk; Harvest F Gu; Boo Johansson; Margaret Gatz; Kaj Blennow; Anthony J Brookes
Journal:  Hum Mutat       Date:  2003-11       Impact factor: 4.878

5.  Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease.

Authors:  G McKhann; D Drachman; M Folstein; R Katzman; D Price; E M Stadlan
Journal:  Neurology       Date:  1984-07       Impact factor: 9.910

6.  Insulin-degrading enzyme and Alzheimer disease: a genetic association study in the Han Chinese.

Authors:  L Bian; J D Yang; T W Guo; Y Sun; S W Duan; W Y Chen; Y X Pan; G Y Feng; L He
Journal:  Neurology       Date:  2004-07-27       Impact factor: 9.910

7.  Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation.

Authors:  W Q Qiu; D M Walsh; Z Ye; K Vekrellis; J Zhang; M B Podlisny; M R Rosner; A Safavi; L B Hersh; D J Selkoe
Journal:  J Biol Chem       Date:  1998-12-04       Impact factor: 5.157

8.  Partial loss-of-function mutations in insulin-degrading enzyme that induce diabetes also impair degradation of amyloid beta-protein.

Authors:  Wesley Farris; Stefan Mansourian; Malcolm A Leissring; Elizabeth A Eckman; Lars Bertram; Christopher B Eckman; Rudolph E Tanzi; Dennis J Selkoe
Journal:  Am J Pathol       Date:  2004-04       Impact factor: 4.307

9.  Clinical and neuropsychological characteristics in familial and sporadic Alzheimer's disease: relation to apolipoprotein E polymorphism.

Authors:  M Lehtovirta; H Soininen; S Helisalmi; A Mannermaa; E L Helkala; P Hartikainen; T Hänninen; M Ryynänen; P J Riekkinen
Journal:  Neurology       Date:  1996-02       Impact factor: 9.910
  9 in total
  16 in total

Review 1.  Innate immune activation in Alzheimer's disease.

Authors:  Ming-Ming Wang; Dan Miao; Xi-Peng Cao; Lin Tan; Lan Tan
Journal:  Ann Transl Med       Date:  2018-05

2.  Anion activation site of insulin-degrading enzyme.

Authors:  Nicholas Noinaj; Eun Suk Song; Sonia Bhasin; Benjamin J Alper; Walter K Schmidt; Louis B Hersh; David W Rodgers
Journal:  J Biol Chem       Date:  2011-11-02       Impact factor: 5.157

3.  Gene-centric analysis of serum cotinine levels in African and European American populations.

Authors:  Ajna Hamidovic; Robert J Goodloe; Andrew W Bergen; Neal L Benowitz; Mindi A Styn; Jay L Kasberger; Helene Choquet; Taylor R Young; Yan Meng; Cameron Palmer; Mark Pletcher; Stefan Kertesz; Brian Hitsman; Bonnie Spring; Eric Jorgenson
Journal:  Neuropsychopharmacology       Date:  2011-11-16       Impact factor: 7.853

4.  Physiological effects of manipulating the level of insulin-degrading enzyme in insulin-producing cells of Drosophila.

Authors:  Joogyung Hyun; Carl Hashimoto
Journal:  Fly (Austin)       Date:  2011-01-01       Impact factor: 2.160

5.  In vitro degradation of insulin-like peptide 3 by insulin-degrading enzyme.

Authors:  Wei-Jie Zhang; Xiao Luo; Zhan-Yun Guo
Journal:  Protein J       Date:  2010-02       Impact factor: 2.371

6.  17β-Estradiol regulates insulin-degrading enzyme expression via an ERβ/PI3-K pathway in hippocampus: relevance to Alzheimer's prevention.

Authors:  Liqin Zhao; Jia Yao; Zisu Mao; Shuhua Chen; Yan Wang; Roberta Diaz Brinton
Journal:  Neurobiol Aging       Date:  2010-01-06       Impact factor: 4.673

7.  A monomeric variant of insulin degrading enzyme (IDE) loses its regulatory properties.

Authors:  Eun Suk Song; David W Rodgers; Louis B Hersh
Journal:  PLoS One       Date:  2010-03-16       Impact factor: 3.240

8.  Enzyme solid-state support assays: a surface plasmon resonance and mass spectrometry coupled study of immobilized insulin degrading enzyme.

Authors:  Giuseppe Grasso; Ashley I Bush; Roberta D'Agata; Enrico Rizzarelli; Giuseppe Spoto
Journal:  Eur Biophys J       Date:  2008-12-02       Impact factor: 1.733

Review 9.  Genetic aspects of Alzheimer disease.

Authors:  Jennifer Williamson; Jill Goldman; Karen S Marder
Journal:  Neurologist       Date:  2009-03       Impact factor: 1.398

10.  Genomic copy number and expression variation within the C57BL/6J inbred mouse strain.

Authors:  Dawn E Watkins-Chow; William J Pavan
Journal:  Genome Res       Date:  2007-11-21       Impact factor: 9.043
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