Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 The current state of knowledge on age, sex, and their interactions on clinical pharmacology.

Literature DB >> 17495875

The current state of knowledge on age, sex, and their interactions on clinical pharmacology.

Abstract

Pharmacokinetic and pharmacodynamic changes occur with increasing age. Sex differences in pharmacokinetics and pharmacodynamics exist and persist at older age. The issue for the clinician is how to best treat the older patient with currently available knowledge. This communication highlights age- and sex-related differences in pharmacokinetics that should influence clinical practice and prescribing guidelines to optimize clinical responses. The most compelling data for sex-specific medication dosing guidelines for older patients are related to volume of distribution differences, or size differences, between the sexes and to differences in glomerular filtration rates.

Entities: Species

Mesh：

Substances：

Year: 2007 PMID： 17495875 DOI： 10.1038/sj.clpt.6100226

Source DB: PubMed Journal: Clin Pharmacol Ther ISSN： 0009-9236 Impact factor: 6.875

Keyword Cloud
Cited

62 in total

1. Pharmacokinetics and tolerability of single and multiple doses of ticagrelor in healthy Chinese subjects: an open-label, sequential, two-cohort, single-centre study.

Authors: Haiyan Li; Kathleen Butler; Li Yang; Zhenghua Yang; Renli Teng
Journal: Clin Drug Investig Date: 2012-02-01 Impact factor: 2.859

2. Long-term safety, tolerability and efficacy of fesoterodine in subjects with overactive bladder symptoms stratified by age: pooled analysis of two open-label extension studies.

Authors: Peter K Sand; John Heesakkers; Stephen R Kraus; Martin Carlsson; Zhonghong Guan; Sandra Berriman
Journal: Drugs Aging Date: 2012-02-01 Impact factor: 3.923

Review 3. The clinical implications of ageing for rational drug therapy.

Authors: Shaojun Shi; Klaus Mörike; Ulrich Klotz
Journal: Eur J Clin Pharmacol Date: 2008-01-05 Impact factor: 2.953

4. Genome-wide analysis of chromatin states reveals distinct mechanisms of sex-dependent gene regulation in male and female mouse liver.

Authors: Aarathi Sugathan; David J Waxman
Journal: Mol Cell Biol Date: 2013-07-08 Impact factor: 4.272

5. Population pharmacokinetics of JNJ-37822681, a selective fast-dissociating dopamine D₂-receptor antagonist, in healthy subjects and subjects with schizophrenia and dose selection based on simulated D₂-receptor occupancy.

Authors: Eef Hoeben; Martine Neyens; Erik Mannaert; Mark Schmidt; An Vermeulen
Journal: Clin Pharmacokinet Date: 2013-11 Impact factor: 6.447

The current state of knowledge on age, sex, and their interactions on clinical pharmacology.

1. Pharmacokinetics and tolerability of single and multiple doses of ticagrelor in healthy Chinese subjects: an open-label, sequential, two-cohort, single-centre study.

2. Long-term safety, tolerability and efficacy of fesoterodine in subjects with overactive bladder symptoms stratified by age: pooled analysis of two open-label extension studies.

Review 3. The clinical implications of ageing for rational drug therapy.

4. Genome-wide analysis of chromatin states reveals distinct mechanisms of sex-dependent gene regulation in male and female mouse liver.

5. Population pharmacokinetics of JNJ-37822681, a selective fast-dissociating dopamine D₂-receptor antagonist, in healthy subjects and subjects with schizophrenia and dose selection based on simulated D₂-receptor occupancy.

Review 6. Identification and management of in-hospital drug-induced delirium in older patients.

7. Should women receive left ventricular assist device support?: findings from INTERMACS.

Review 8. Physiologically-based pharmacokinetic models: approaches for enabling personalized medicine.

9. Effects of gender and age on serum concentrations of antidepressants under naturalistic conditions.

10. Tolerability of Antiseizure Medications in Individuals With Newly Diagnosed Epilepsy.