OBJECTIVE: To assess changes in body composition with weight loss in obese subjects randomized to a laparoscopic adjustable gastric band surgical program or a medical program using a very-low-energy diet and orlistat. RESEARCH METHODS AND PROCEDURES: Using body composition measurements by DXA, neutron activation for total body nitrogen, and whole body gamma counting for total body potassium, we studied changes in fat mass, fat distribution, fat-free mass, total bone mineral content, total body protein, and body cell mass at 6 (n = 61 paired) and 24 months (n = 53 paired) after randomization. RESULTS: At 24 months, the surgical group had lost significantly more weight (surgical, 20.3 +/- 6.5 kg; medical, 5.9 +/- 8.0 kg). There was favorable fat-free mass to fat mass loss ratios for both groups (surgical, 1:5.5; medical, 1:5.9). Changes in total body nitrogen or potassium were favorable in each group. A small reduction in mean bone mineral content occurred throughout the study but was not associated with extent of weight loss or treatment group. At 6 months, weight loss for both groups was similar (surgical, 14.1 +/- 4.5 kg; medical, 13.3 +/- 7.3 kg). The medical program subjects lost less fat-free mass and skeletal muscle and had increased total body protein. The proportion of body fat to limb fat remained remarkably constant throughout the study. DISCUSSION: Weight loss programs used in this study induced fat loss without significant deleterious effects on the components of fat-free mass.
RCT Entities:
OBJECTIVE: To assess changes in body composition with weight loss in obese subjects randomized to a laparoscopic adjustable gastric band surgical program or a medical program using a very-low-energy diet and orlistat. RESEARCH METHODS AND PROCEDURES: Using body composition measurements by DXA, neutron activation for total body nitrogen, and whole body gamma counting for total body potassium, we studied changes in fat mass, fat distribution, fat-free mass, total bone mineral content, total body protein, and body cell mass at 6 (n = 61 paired) and 24 months (n = 53 paired) after randomization. RESULTS: At 24 months, the surgical group had lost significantly more weight (surgical, 20.3 +/- 6.5 kg; medical, 5.9 +/- 8.0 kg). There was favorable fat-free mass to fat mass loss ratios for both groups (surgical, 1:5.5; medical, 1:5.9). Changes in total body nitrogen or potassium were favorable in each group. A small reduction in mean bone mineral content occurred throughout the study but was not associated with extent of weight loss or treatment group. At 6 months, weight loss for both groups was similar (surgical, 14.1 +/- 4.5 kg; medical, 13.3 +/- 7.3 kg). The medical program subjects lost less fat-free mass and skeletal muscle and had increased total body protein. The proportion of body fat to limb fat remained remarkably constant throughout the study. DISCUSSION: Weight loss programs used in this study induced fat loss without significant deleterious effects on the components of fat-free mass.
Authors: N Nguyen; J K Champion; J Ponce; B Quebbemann; E Patterson; B Pham; W Raum; J N Buchwald; G Segato; F Favretti Journal: Obes Surg Date: 2012-06 Impact factor: 4.129
Authors: Diana Thomas; Sai Krupa Das; James A Levine; Corby K Martin; Laurel Mayer; Andrew McDougall; Boyd J Strauss; Steven B Heymsfield Journal: Nutr Metab (Lond) Date: 2010-05-09 Impact factor: 4.169
Authors: Ted D Adams; Robert C Pendleton; Michael B Strong; Ronette L Kolotkin; James M Walker; Sheldon E Litwin; Wael K Berjaoui; Michael J LaMonte; Tom V Cloward; Erick Avelar; Theophilus E Owan; Robert T Nuttall; Richard E Gress; Ross D Crosby; Paul N Hopkins; Eliot A Brinton; Wayne D Rosamond; Gail A Wiebke; Frank G Yanowitz; Robert J Farney; R Chad Halverson; Steven C Simper; Sherman C Smith; Steven C Hunt Journal: Obesity (Silver Spring) Date: 2009-06-04 Impact factor: 5.002