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Literature DB >> 17494063

Function of the respiratory syncytial virus small hydrophobic protein.

Sandra Fuentes¹, Kim C Tran, Priya Luthra, Michael N Teng, Biao He.

Abstract

Respiratory syncytial virus (RSV), a member of the Paramyxoviridae family, encodes a small hydrophobic (SH) protein of unknown function. Parainfluenza virus 5 (PIV5), a prototypical paramyxovirus, also encodes an SH protein, which inhibits tumor necrosis factor alpha (TNF-alpha) signaling. In this study, recombinant PIV5 viruses without their own SH but containing RSV SH (from RSV strain A2 or B1) in its place (PIV5DeltaSH-RSV SH) and RSV lacking its own SH (RSVDeltaSH) were generated and analyzed. The results indicate that the SH protein of RSV has a function similar to that of PIV5 SH and that it can inhibit TNF-alpha signaling.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2007 PMID： 17494063 PMCID： PMC1951288 DOI： 10.1128/JVI.02717-06

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

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