Literature DB >> 1749377

DNA-protein cross-linking in L1210 cells sensitive and resistant to cis-diamminedichloroplatinum (II).

R Olinski1, R C Briggs.   

Abstract

The role of restricted cellular accumulation of cis-diamminedichloroplatinum(II) (cis-DDP) and altered repair of DNA-Pt-protein cross-links in the mechanism of L1210 murine leukemia cell resistance was examined. An immunochemical method was used to analyze the formation and removal of DNA-Pt-protein complexes in L1210 cells sensitive and resistant to cis-DDP. The accumulation of Pt into the cells and the binding of Pt to the DNA was measured by atomic absorption spectroscopy. The results demonstrated that both decreased accumulation of the drug and the rate of DNA-Pt protein cross-link removal may be important factors in L1210 cell resistance to cis-DDP.

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Year:  1991        PMID： 1749377     DOI： 10.1007/bf00364843

Source DB:  PubMed          Journal:  Mol Biol Rep        ISSN： 0301-4851            Impact factor:   2.316


  18 in total

1.  Tissue differences in antigenic properties of non-histone protein-DNA complexes.

Authors:  F Chytil; T C Spelsberg
Journal:  Nat New Biol       Date:  1971-10-13

2.  The mechanism of action of antitumor platinum compounds.

Authors:  J J Roberts; A J Thomson
Journal:  Prog Nucleic Acid Res Mol Biol       Date:  1979

3.  Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

Authors:  U K Laemmli
Journal:  Nature       Date:  1970-08-15       Impact factor: 49.962

4.  The role of DNA repair in the recovery of human cells from cisplatin toxicity.

Authors:  M F Pera; C J Rawlings; J J Roberts
Journal:  Chem Biol Interact       Date:  1981-10       Impact factor: 5.192

Review 5.  Fundamental studies with cisplatin.

Authors:  B Rosenberg
Journal:  Cancer       Date:  1985-05-15       Impact factor: 6.860

Review 6.  Relationships between functionality and genetic toxicology of selected DNA-damaging agents.

Authors:  M Brendel; A Ruhland
Journal:  Mutat Res       Date:  1984-01       Impact factor: 2.433

Review 7.  Binding of the antitumor drug cis-diamminedichloroplatinum(II) (cisplatin) to DNA.

Authors:  A L Pinto; S J Lippard
Journal:  Biochim Biophys Acta       Date:  1985

8.  Induction and repair of DNA cross-links in chinese hamster ovary cells treated with various platinum coordination compounds in relation to platinum binding to DNA, cytotoxicity, mutagenicity, and antitumor activity.

Authors:  A C Plooy; M van Dijk; P H Lohman
Journal:  Cancer Res       Date:  1984-05       Impact factor: 12.701

9.  Differential uptake of cis-diamminedichloroplatinum (II) by sensitive and resistant murine L1210 leukemia cells.

Authors:  W R Waud
Journal:  Cancer Res       Date:  1987-12-15       Impact factor: 12.701

10.  cis-Platinum: subcellular distribution and binding to cytosolic ligands.

Authors:  R P Sharma; I R Edwards
Journal:  Biochem Pharmacol       Date:  1983-09-15       Impact factor: 5.858
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  2 in total

1.  DNA-protein cross-linking by trans-[PtCl(2)(E-iminoether)(2)]. A concept for activation of the trans geometry in platinum antitumor complexes.

Authors:  Olga Novakova; Jana Kasparkova; Jaroslav Malina; Giovanni Natile; Viktor Brabec
Journal:  Nucleic Acids Res       Date:  2003-11-15       Impact factor: 16.971

2.  Mechanism of the formation of DNA-protein cross-links by antitumor cisplatin.

Authors:  Katerina Chválová; Viktor Brabec; Jana Kaspárková
Journal:  Nucleic Acids Res       Date:  2007-02-28       Impact factor: 16.971
  2 in total

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