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Literature DB >> 1749213

Fetal and neonatal bile acid synthesis and metabolism--clinical implications.

Abstract

It has become apparent that with sophisticated technology we are now able to recognize defective bile acid metabolism in a wide variety of disease states. Recognition of specific aberrations, such as inborn errors in bile acid metabolism manifesting as neonatal cholestasis, offers new opportunities for therapeutic intervention. Future studies should determine the incidence of inborn errors in patients with enigmatic and unexplained liver diseases such as idiopathic neonatal hepatitis.

Entities: Chemical Disease Species

Mesh：

Substances：
Bile Acids and Salts

Year: 1991 PMID： 1749213 DOI： 10.1007/bf01797918

Source DB: PubMed Journal: J Inherit Metab Dis ISSN： 0141-8955 Impact factor: 4.982

61 in total

Review 1. New concepts of mechanisms of hepatocyte bile formation.

Authors: J L Boyer
Journal: Physiol Rev Date: 1980-04 Impact factor: 37.312

2. Serum-bile-acids in the stagnant-loop syndrome.

Authors: B Lewis; S Tabaqchali; D Panveliwalla; I D Wootton
Journal: Lancet Date: 1969-02-01 Impact factor: 79.321

Review 3. Immaturity of the enterohepatic circulation in early life: factors predisposing to "physiologic" maldigestion and cholestasis.

Authors: W F Balistreri; J E Heubi; F J Suchy
Journal: J Pediatr Gastroenterol Nutr Date: 1983-05 Impact factor: 2.839

Fetal and neonatal bile acid synthesis and metabolism--clinical implications.

Review 1. New concepts of mechanisms of hepatocyte bile formation.

2. Serum-bile-acids in the stagnant-loop syndrome.

Review 3. Immaturity of the enterohepatic circulation in early life: factors predisposing to "physiologic" maldigestion and cholestasis.

4. Production of bile duct hyperplasia and gallstones by lithocholic acid.

5. Bile-salt metabolism in the primate fetus.

6. Colonic secretion of water and electrolytes induced by bile acids: perfusion studies in man.

7. Influence of bile acid structure on bile flow and biliary lipid secretion in the hamster.

8. Developmental pattern of bile acid metabolism as revealed by bile acid analysis of meconium.

9. Bile salt metabolism in the first year of life.

10. The effect of bile acids on colonic myoelectrical activity.

Review 1. Inborn errors of bile acid metabolism.