| Literature DB >> 17490877 |
Martin C Clasby1, Samuel Chackalamannil, Michael Czarniecki, Darío Doller, Keith Eagen, William J Greenlee, Yan Lin, Jayaram R Tagat, Hsingan Tsai, Yan Xia, Ho-Sam Ahn, Jacqueline Agans-Fantuzzi, George Boykow, Madhu Chintala, Yunsheng Hsieh, Andrew T McPhail.
Abstract
The synthesis and biological activity of a novel series of thrombin receptor antagonists is described. This series of compounds showed excellent in vitro and in vivo potency. The most potent compound 40 had an IC(50) of 7.6 nM and showed robust inhibition of platelet aggregation in a cynomolgus monkey model after oral administration.Entities:
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Year: 2007 PMID： 17490877 DOI： 10.1016/j.bmcl.2007.04.061
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823