Literature DB >> 17490875

Dihydro-[1H]-quinolin-2-ones as retinoid X receptor (RXR) agonists for potential treatment of dyslipidemia.

Bharat Lagu1, Rimma Lebedev, Barbara Pio, Maria Yang, Patricia D Pelton.   

Abstract

A number of RXR modulators with novel structural features were synthesized and screened in the functional assays. The synthesis and the structure-activity relationship within the series of compounds will be presented. Some in vivo data generated in the models for dyslipidemia and diabetes will also be presented.

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Year:  2007        PMID: 17490875     DOI: 10.1016/j.bmcl.2007.01.049

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  1 in total

1.  α-Lithiation and electrophilic substitution of 1,4,4-trimethyl-3,4-dihydroquinolin-2-one.

Authors:  Bouclé Sébastien; Guillard Jérôme; Viaud-Massuard Marie-Claude
Journal:  Molecules       Date:  2010-10-29       Impact factor: 4.411

  1 in total

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