| Literature DB >> 17490874 |
Yang Yu1, Di Liu, Chunsheng Liu, Genxiang Luo.
Abstract
A simple and effective synthesis of 3,4-dihydropyrimidin-2(1H)-one derivatives from aldehydes, 1,3-dicarbonyl compounds and urea or thiourea using chloroacetic acid as catalyst under solvent-free conditions is described. Compared with the classical Biginelli reaction conditions, this new method has the advantage of good to excellent yields and short reaction time.Entities:
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Year: 2006 PMID： 17490874 DOI： 10.1016/j.bmcl.2006.12.068
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823