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Literature DB >> 17489570

The potential of transient receptor potential vanilloid type 1 channel modulators for the treatment of pain.

Susan M Westaway¹.

Abstract

Entities: Disease

Mesh：

Substances：

Year: 2007 PMID： 17489570 DOI： 10.1021/jm060637e

Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446

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9 in total

1. Differential modulation of agonist and antagonist structure activity relations for rat TRPV1 by cyclosporin A and other protein phosphatase inhibitors.

Authors: Larry V Pearce; Attila Toth; HyungChul Ryu; Dong Wook Kang; Hyun-Kyung Choi; Mi-Kyoung Jin; Jeewoo Lee; Peter M Blumberg
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 2008-02-08 Impact factor: 3.000

2. Conformationally constrained analogues of N'-(4-tert-butylbenzyl)-N-(4-methylsulfonylaminobenzyl)thiourea as TRPV1 antagonists.

Authors: Ju-Ok Lim; Mi-Kyoung Jin; HyungChul Ryu; Dong Wook Kang; Jeewoo Lee; Larry V Pearce; Richard Tran; Attila Toth; Peter M Blumberg
Journal: Eur J Med Chem Date: 2008-03-07 Impact factor: 6.514

3. Halogenation of 4-hydroxy/amino-3-methoxyphenyl acetamide TRPV1 agonists showed enhanced antagonism to capsaicin.

Authors: Dong Wook Kang; Yong Soo Kim; Kwang Su Lim; Myeong Seop Kim; Larry V Pearce; Vladimir A Pavlyukovets; Andy K Tao; Krystle A Lang-Kuhs; Peter M Blumberg; Jeewoo Lee
Journal: Bioorg Med Chem Date: 2010-09-18 Impact factor: 3.641

4. Inhibition of FAAH, TRPV1, and COX2 by NSAID-serotonin conjugates.

Authors: Tyler M Rose; Christopher A Reilly; Cassandra E Deering-Rice; Clinton Brewster; Chelsea Brewster
Journal: Bioorg Med Chem Lett Date: 2014-10-28 Impact factor: 2.823

5. Neurokinin 2 receptor-mediated activation of protein kinase C modulates capsaicin responses in DRG neurons from adult rats.

Authors: Adrian Sculptoreanu; F Aura Kullmann; William C de Groat
Journal: Eur J Neurosci Date: 2008-06 Impact factor: 3.386

The potential of transient receptor potential vanilloid type 1 channel modulators for the treatment of pain.

1. Differential modulation of agonist and antagonist structure activity relations for rat TRPV1 by cyclosporin A and other protein phosphatase inhibitors.

2. Conformationally constrained analogues of N'-(4-tert-butylbenzyl)-N-(4-methylsulfonylaminobenzyl)thiourea as TRPV1 antagonists.

3. Halogenation of 4-hydroxy/amino-3-methoxyphenyl acetamide TRPV1 agonists showed enhanced antagonism to capsaicin.

4. Inhibition of FAAH, TRPV1, and COX2 by NSAID-serotonin conjugates.

5. Neurokinin 2 receptor-mediated activation of protein kinase C modulates capsaicin responses in DRG neurons from adult rats.

6. The SAR analysis of TRPV1 agonists with the α-methylated B-region.

7. Current and emerging "at-site" pain medications: a review.

8. Empowering pharmacoinformatics by linked life science data.

9. Novel scaffolds for modulation of TRPV1 identified with pharmacophore modeling and virtual screening.