Literature DB >> 17489354

A new cytotoxic prenylated chalcone from Sophora flavescens.

Jae Hyeok Lee1, Nam-In Baek, Sung-Hoon Kim, Hee Wook Park, Jae Heon Yang, Jeong Joo Lee, Seong Jin Kim, Seung il Jeong, Chan-Ho Oh, Kyu-Hee Lee, Dae Keun Kim.   

Abstract

We have isolated a new prenylated chalcone from the roots of Sophora flavescens (Leguminosae). We determined that structure of this compound is 7,9,2',4'-tetrahydroxy-8-isopentenyl-5-methoxychalcone (1) on the basis of spectroscopic analysis (1D and 2D NMR data). Compound 1 exhibited potent cytotoxicity against human acute promyelocytic (HL60), mouse lymphocytic (L1210) and human histiocytic (U937) leukemia cells.

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Year:  2007        PMID： 17489354     DOI： 10.1007/bf02980212

Source DB:  PubMed          Journal:  Arch Pharm Res        ISSN： 0253-6269            Impact factor:   4.946


  4 in total

1.  An update on antitumor activity of naturally occurring chalcones.

Authors:  En-Hui Zhang; Ru-Feng Wang; Shu-Zhen Guo; Bin Liu
Journal:  Evid Based Complement Alternat Med       Date:  2013-04-17       Impact factor: 2.629

Review 2.  Targeting apoptosis pathways in cancer with alantolactone and isoalantolactone.

Authors:  Azhar Rasul; Muhammad Khan; Muhammad Ali; Jiang Li; Xiaomeng Li
Journal:  ScientificWorldJournal       Date:  2013-10-27

3.  Reactive oxygen species mediate isoalantolactone-induced apoptosis in human prostate cancer cells.

Authors:  Azhar Rasul; Jun Di; Faya Martin Millimouno; Mahadev Malhi; Ichiro Tsuji; Muhammad Ali; Jiang Li; Xiaomeng Li
Journal:  Molecules       Date:  2013-08-05       Impact factor: 4.411

4.  Induction of apoptosis by costunolide in bladder cancer cells is mediated through ROS generation and mitochondrial dysfunction.

Authors:  Azhar Rasul; Rui Bao; Mahadev Malhi; Bing Zhao; Ichiro Tsuji; Jiang Li; Xiaomeng Li
Journal:  Molecules       Date:  2013-01-24       Impact factor: 4.411
  4 in total

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