Literature DB >> 17488862

Is cocaine use recognised as a risk factor for acute coronary syndrome by doctors in the UK?

David M Wood1, Duncan Hill, Awini Gunasekera, Shaun L Greene, Alison L Jones, Paul I Dargan.   

Abstract

BACKGROUND: Cocaine is a sympathomimetic agent that can cause coronary artery vasospasm leading to myocardial ischaemia, acute coronary syndrome and acute myocardial infarction (ACS/AMI). The management of cocaine-induced ACS/AMI is different to classical atheromatous ACS/MI, because the mechanisms are different.
METHODS: Knowledge study--Junior medical staff were given a scenario of a patient with ACS and asked to identify potential risk factors for ACS and which ones they routinely asked about in clinical practice. Retrospective study--Retrospective notes reviews of patients with suspected and proven (elevated troponin T concentration) ACS were undertaken to determine the recording of cocaine use/non-use in clinical notes.
RESULTS: Knowledge study--There was no significant difference in the knowledge that cocaine was a risk factor compared to other "classical" cardiovascular risk factors, but juniors doctors were less likely to ask routinely about cocaine use compared to other "classical" risk factors (52.9% vs >90%, respectively). Retrospective study--Cocaine use or non-use was documented in 3.7% (4/109) and 4% (2/50) of clinical notes of patients with suspected and proven ACS, respectively. DISCUSSION: Although junior medical staff are aware that cocaine is a risk factor for ACS/AMI, they are less likely to ask about it in routine clinical practice or record its use/non-use in clinical notes. It is essential that patients presenting with suspected ACS are asked about cocaine use, since the management of these patients is different to those with ACS secondary to "classical" cardiovascular risk factors.

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Year:  2007        PMID: 17488862      PMCID: PMC2600067          DOI: 10.1136/pgmj.2006.053850

Source DB:  PubMed          Journal:  Postgrad Med J        ISSN: 0032-5473            Impact factor:   2.401


  21 in total

1.  Cardiovascular complications of cocaine use.

Authors:  R A Lange; L D Hillis
Journal:  N Engl J Med       Date:  2001-08-02       Impact factor: 91.245

2.  Frequency of coronary artery disease and left ventricle dysfunction in cocaine users.

Authors:  A Om; M Warner; N Sabri; L Cecich; G Vetrovec
Journal:  Am J Cardiol       Date:  1992-06-15       Impact factor: 2.778

3.  Cocaine use and the likelihood of nonfatal myocardial infarction and stroke: data from the Third National Health and Nutrition Examination Survey.

Authors:  A I Qureshi; M F Suri; L R Guterman; L N Hopkins
Journal:  Circulation       Date:  2001-01-30       Impact factor: 29.690

4.  "Abnormal" electrocardiograms in patients with cocaine-associated chest pain are due to "normal" variants.

Authors:  J E Hollander; M Lozano; P Fairweather; E Goldstein; P Gennis; G X Brogan; D Cooling; H C Thode; E J Gallagher
Journal:  J Emerg Med       Date:  1994 Mar-Apr       Impact factor: 1.484

5.  Frequency and type of electrocardiographic abnormalities in cocaine abusers (electrocardiogram in cocaine abuse).

Authors:  S Chakko; S Sepulveda; K M Kessler; M C Sotomayor; D C Mash; R J Prineas; R J Myerburg
Journal:  Am J Cardiol       Date:  1994-10-01       Impact factor: 2.778

6.  Cocaine use in an urban medical population and the development of angiographically significant coronary artery disease.

Authors:  Amar D Patel; Srikanth Sola; Patrick Caneer; Faiz A Cheema; Divya Gupta; Tarek Helmy; Bobby V Khan
Journal:  Prev Cardiol       Date:  2006

7.  Myocardial hypertrophy and coronary artery disease in male cocaine users.

Authors:  S B Karch; G S Green; S Young
Journal:  J Forensic Sci       Date:  1995-07       Impact factor: 1.832

8.  Potentiation of cocaine-induced coronary vasoconstriction by beta-adrenergic blockade.

Authors:  R A Lange; R G Cigarroa; E D Flores; W McBride; A S Kim; P J Wells; J B Bedotto; R S Danziger; L D Hillis
Journal:  Ann Intern Med       Date:  1990-06-15       Impact factor: 25.391

9.  Chest pain associated with cocaine: an assessment of prevalence in suburban and urban emergency departments.

Authors:  J E Hollander; K H Todd; G Green; K L Heilpern; D J Karras; A J Singer; G X Brogan; J P Funk; J B Strahan
Journal:  Ann Emerg Med       Date:  1995-12       Impact factor: 5.721

Review 10.  Cardiac effects of cocaine: a review.

Authors:  A H Gradman
Journal:  Yale J Biol Med       Date:  1988 Mar-Apr
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  2 in total

1.  Putting cocaine use and cocaine-associated cardiac arrhythmias into epidemiological and clinical perspective.

Authors:  David M Wood; Paul I Dargan
Journal:  Br J Clin Pharmacol       Date:  2010-05       Impact factor: 4.335

2.  Undisclosed cocaine use and chest pain in emergency departments of Spain.

Authors:  Guillermo Burillo-Putze; Beatriz López; Juan María Borreguero León; Miquel Sánchez Sánchez; Martin García González; Alberto Domínguez Rodriguez; Eva Vallbona Afonso; Alejandro Jiménez Sosa; Oscar Mirò
Journal:  Scand J Trauma Resusc Emerg Med       Date:  2009-03-02       Impact factor: 2.953

  2 in total

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