CONTEXT: The IGF2 gene (IGF2) plays a key role in growth and is a candidate for association with obesity. Previous studies have reported that polymorphisms in IGF2 are associated with body weight and body mass index (BMI), but the results have been inconsistent. OBJECTIVES: The aim of this study was primarily to confirm the association with BMI and, secondarily, to study the associations with other indices of body size. METHODS: In a sample of 2797 women and 2203 men aged 39-79 participating in the Norfolk arm of the European Prospective Investigation of Cancer, we genotyped three single nucleotide polymorphisms (SNPs) in the IGF2 gene that were previously associated with BMI [6815 A/T, 1156 T/C (G/A), and 820 G/A (ApaI)]. RESULTS: No significant associations were observed between these SNPs and BMI. However, all three SNPs were significantly associated with height (P = 0.03 to 0.001). In a backward elimination regression analysis, two SNPs, 1156 T/C (G/A) and 820 G/A, remained independently associated with height (P = 0.003 and P = 0.038, respectively). Haplotype analysis of these two SNPs showed that carriers of the GA haplotype were shorter than carriers of each of the other three haplotypes (P < 0.001 for all comparisons). CONCLUSIONS: We did not confirm the previously reported associations between IGF2 polymorphisms and BMI. However, our results suggest that common variation in the IGF2 gene may be associated with adult height. IGF2 could be considered as a candidate gene for future research on mechanisms for the association between height and chronic diseases, such as cancer, diabetes, and coronary heart disease.
CONTEXT: The IGF2 gene (IGF2) plays a key role in growth and is a candidate for association with obesity. Previous studies have reported that polymorphisms in IGF2 are associated with body weight and body mass index (BMI), but the results have been inconsistent. OBJECTIVES: The aim of this study was primarily to confirm the association with BMI and, secondarily, to study the associations with other indices of body size. METHODS: In a sample of 2797 women and 2203 men aged 39-79 participating in the Norfolk arm of the European Prospective Investigation of Cancer, we genotyped three single nucleotide polymorphisms (SNPs) in the IGF2 gene that were previously associated with BMI [6815 A/T, 1156 T/C (G/A), and 820 G/A (ApaI)]. RESULTS: No significant associations were observed between these SNPs and BMI. However, all three SNPs were significantly associated with height (P = 0.03 to 0.001). In a backward elimination regression analysis, two SNPs, 1156 T/C (G/A) and 820 G/A, remained independently associated with height (P = 0.003 and P = 0.038, respectively). Haplotype analysis of these two SNPs showed that carriers of the GA haplotype were shorter than carriers of each of the other three haplotypes (P < 0.001 for all comparisons). CONCLUSIONS: We did not confirm the previously reported associations between IGF2 polymorphisms and BMI. However, our results suggest that common variation in the IGF2 gene may be associated with adult height. IGF2 could be considered as a candidate gene for future research on mechanisms for the association between height and chronic diseases, such as cancer, diabetes, and coronary heart disease.
Authors: S D O'Dell; G J Miller; J A Cooper; P C Hindmarsh; P J Pringle; H Ford; S E Humphries; I N Day Journal: Int J Obes Relat Metab Disord Date: 1997-09
Authors: Santiago Rodríguez; Tom R Gaunt; Sandra D O'Dell; Xiao-He Chen; Dongfeng Gu; Emma Hawe; George J Miller; Stephen E Humphries; Ian N M Day Journal: Hum Mol Genet Date: 2004-01-28 Impact factor: 6.150
Authors: Ellen Perkins; Susan K Murphy; Amy P Murtha; Joellen Schildkraut; Randy L Jirtle; Wendy Demark-Wahnefried; Michele R Forman; Joanne Kurtzberg; Francine Overcash; Zhiqing Huang; Cathrine Hoyo Journal: J Pediatr Date: 2012-02-17 Impact factor: 4.406
Authors: Ronald M Adkins; Grant Somes; John C Morrison; James B Hill; Erin M Watson; Everett F Magann; Julia Krushkal Journal: Pediatr Res Date: 2010-11 Impact factor: 3.756
Authors: Hideo Suzuki; Yanan Li; Xiaoqun Dong; Manal M Hassan; James L Abbruzzese; Donghui Li Journal: Cancer Epidemiol Biomarkers Prev Date: 2008-12 Impact factor: 4.254
Authors: Rae-Chi Huang; John C Galati; Sally Burrows; Lawrence J Beilin; Xin Li; Craig E Pennell; Jam van Eekelen; Trevor A Mori; Leon A Adams; Jeffrey M Craig Journal: Clin Epigenetics Date: 2012-11-13 Impact factor: 6.551
Authors: Djeda Belharazem; Matthias Kirchner; Franziska Geissler; Peter Bugert; Martin Spahn; Burkhard Kneitz; Hubertus Riedmiller; Christian Sauer; Stefan Küffer; Lutz Trojan; Christian Bolenz; Maurice Stephan Michel; Alexander Marx; Philipp Ströbel Journal: Endocr Connect Date: 2012-10-24 Impact factor: 3.335