Literature DB >> 17488703

Human leukocyte antigens HLA DRB1 influence clinical outcome of chronic lymphocytic leukemia?

Ewa Lech-Maranda, Przemyslaw Juszczynski, Anna Szmigielska-Kaplon, Krzysztof Jamroziak, Ewa Balcerczak, Tadeusz Robak.   

Abstract

We investigated HLA DRB1 correlations with chronic lymphocytic leukemia (B-CLL) outcome in 90 patients. Neither of the alleles was associated with B-CLL clinical characteristics or mortality. HLA DRB1*01 and HLA DRB1*02-null were associated with shorter overall survival (p=0.007, p=0.002). Our results suggest that HLA-restricted adaptive immunity influences CLL outcome.

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Year:  2007        PMID： 17488703     DOI： 10.3324/haematol.10910

Source DB:  PubMed          Journal:  Haematologica        ISSN： 0390-6078            Impact factor:   9.941


  3 in total

Review 1.  Emerging therapies provide new opportunities to reshape the multifaceted interactions between the immune system and lymphoma cells.

Authors:  M Pizzi; M Boi; F Bertoni; G Inghirami
Journal:  Leukemia       Date:  2016-06-08       Impact factor: 11.528

2.  Associations of Human Leukocyte Antigen-DRB1 Alleles with Nasopharyngeal Carcinoma and Its Clinical Significance in Xinjiang Uyghur Autonomous Region of China.

Authors:  Xiao-Tao Geng; Yun-Hui Hu; Tao Dong; Ruo-Zheng Wang
Journal:  Chin Med J (Engl)       Date:  2016-06-05       Impact factor: 2.628

3.  HLA specificities are associated with prognosis in IGHV-mutated CLL-like high-count monoclonal B cell lymphocytosis.

Authors:  María García-Álvarez; Miguel Alcoceba; Miriam López-Parra; Noemí Puig; Alicia Antón; Ana Balanzategui; Isabel Prieto-Conde; Cristina Jiménez; María E Sarasquete; M Carmen Chillón; María Laura Gutiérrez; Rocío Corral; José María Alonso; José Antonio Queizán; Julia Vidán; Emilia Pardal; María Jesús Peñarrubia; José M Bastida; Ramón García-Sanz; Luis Marín; Marcos González
Journal:  PLoS One       Date:  2017-03-01       Impact factor: 3.240
  3 in total

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