Expression of betaE and gamma-globin genes in infants heterozygous for hemoglobin E and double heterozygous for hemoglobin E and alpha-thalassemia.

This study described the expression of betaE-globin in newborns heterozygous for HbE. Despite the lower level of HbE, the pattern of betaE-globin gene expression was similar to betaA-globin because the increase in HbE and HbA reached the peak level at the same time. A delayed decline of HbF was observed.