| Literature DB >> 17488665 |
Gesine Bug1, Kerstin Schwarz, Claudia Schoch, Manuela Kampfmann, Reinhard Henschler, Dieter Hoelzer, Oliver G Ottmann, Martin Ruthardt.
Abstract
Histone deacetylase inhibitor valproic acid (VPA) was recently shown to enhance proliferation and self-renewal of normal hematopoietic stem cells, raising the possibility that VPA may also support growth of leukemic progenitor cells (LPC). Here, VPA maintains a significantly higher proportion of CD34+ LPC and colony forming units compared to control cultures in six AML samples, but selectively reduces leukemic cell numbers in another AML sample with expression of AML1/ETO. Our data suggest a differential effect of VPA on the small population of AML progenitor cells and the bulk of aberrantly differentiated blasts in the majority of AML samples tested.Entities:
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Year: 2007 PMID： 17488665 DOI： 10.3324/haematol.10758
Source DB: PubMed Journal: Haematologica ISSN： 0390-6078 Impact factor: 9.941