Literature DB >> 17488634

Targeting fat to prevent diabetes.

Jaswinder K Sethi1, Antonio J Vidal-Puig.   

Abstract

An emerging view is that obesity causes metabolic problems when adipose tissue fails to meet the increased demands for fat storage. A study in this issue of Cell Metabolism (Waki et al., 2007) has identified harmine as a proadipogenic small molecule that promotes energy expenditure in white adipose tissue and delays the onset of obesity-associated diabetes.

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Year:  2007        PMID： 17488634      PMCID： PMC4303763          DOI： 10.1016/j.cmet.2007.04.006

Source DB:  PubMed          Journal:  Cell Metab        ISSN： 1550-4131            Impact factor:   27.287


  8 in total

1.  The small molecule harmine is an antidiabetic cell-type-specific regulator of PPARgamma expression.

Authors:  Hironori Waki; Kye Won Park; Nico Mitro; Liming Pei; Robert Damoiseaux; Damien C Wilpitz; Karen Reue; Enrique Saez; Peter Tontonoz
Journal:  Cell Metab       Date:  2007-05       Impact factor: 27.287

2.  Decreased brown adipocyte recruitment and thermogenic capacity in mice with impaired peroxisome proliferator-activated receptor (P465L PPARgamma) function.

Authors:  Sarah L Gray; Edoardo Dalla Nora; Emma C Backlund; Monia Manieri; Sam Virtue; Robert C Noland; Stephen O'Rahilly; Ronald N Cortright; Saverio Cinti; Barbara Cannon; Antonio Vidal-Puig
Journal:  Endocrinology       Date:  2006-09-15       Impact factor: 4.736

3.  Peroxisome proliferator-activated receptor gamma is expressed in hippocampal neurons and its activation prevents beta-amyloid neurodegeneration: role of Wnt signaling.

Authors:  Nibaldo C Inestrosa; Juan A Godoy; Rodrigo A Quintanilla; Cecilia S Koenig; Miguel Bronfman
Journal:  Exp Cell Res       Date:  2004-12-10       Impact factor: 3.905

4.  Functional interaction between peroxisome proliferator-activated receptor gamma and beta-catenin.

Authors:  Jiajian Liu; Hong Wang; Ying Zuo; Stephen R Farmer
Journal:  Mol Cell Biol       Date:  2006-08       Impact factor: 4.272

5.  Effects of the beta-carbolines, harmane and pinoline, on insulin secretion from isolated human islets of Langerhans.

Authors:  E Jane Cooper; Alan L Hudson; Christine A Parker; Noel G Morgan
Journal:  Eur J Pharmacol       Date:  2003-12-15       Impact factor: 4.432

6.  Comparative effects of efaroxan and beta-carbolines on the secretory activity of rodent and human beta cells.

Authors:  Noel G Morgan; E Jane Cooper; Paul E Squires; Claire E Hills; Christine A Parker; Alan L Hudson
Journal:  Ann N Y Acad Sci       Date:  2003-12       Impact factor: 5.691

7.  Peroxisome-proliferator-activated receptor gamma suppresses Wnt/beta-catenin signalling during adipogenesis.

Authors:  Marthe Moldes; Ying Zuo; Ron F Morrison; David Silva; Bae-Hang Park; Jiajian Liu; Stephen R Farmer
Journal:  Biochem J       Date:  2003-12-15       Impact factor: 3.857

8.  Tumour necrosis factor-alpha inhibits adipogenesis via a beta-catenin/TCF4(TCF7L2)-dependent pathway.

Authors:  W P Cawthorn; F Heyd; K Hegyi; J K Sethi
Journal:  Cell Death Differ       Date:  2007-04-20       Impact factor: 15.828
  8 in total
  5 in total

1.  Increased adipose tissue expression of lipocalin-2 in obesity is related to inflammation and matrix metalloproteinase-2 and metalloproteinase-9 activities in humans.

Authors:  V Catalán; J Gómez-Ambrosi; A Rodríguez; B Ramírez; C Silva; F Rotellar; M J Gil; J A Cienfuegos; J Salvador; G Frühbeck
Journal:  J Mol Med (Berl)       Date:  2009-05-23       Impact factor: 4.599

2.  Adipose tissue characteristics related to weight z-score in childhood.

Authors:  Juan Jesus Haro-Mora; Eva Garcia-Escobar; Nuria Porras; Dolores Alcazar; Joaquin Gaztambide; Antonio Ruiz-Orpez; Sara Garcia-Serrano; Juan M Gomez-Zumaquero; Eduardo Garcia-Fuentes; Juan P Lopez-Siguero; Federico Soriguer; Gemma Rojo-Martinez
Journal:  Int J Endocrinol Metab       Date:  2013-04-01

Review 3.  Role of nuclear receptor corepressor RIP140 in metabolic syndrome.

Authors:  Meritxell Rosell; Marius C Jones; Malcolm G Parker
Journal:  Biochim Biophys Acta       Date:  2010-12-28

4.  Harmine Induces Adipocyte Thermogenesis through RAC1-MEK-ERK-CHD4 Axis.

Authors:  Tao Nie; Xiaoyan Hui; Liufeng Mao; Baoming Nie; Kuai Li; Wei Sun; Xuefei Gao; Xiaofeng Tang; Yong Xu; Baishan Jiang; Zhengcao Tu; Peng Li; Ke Ding; Weiping Han; Shaoping Zhang; Aimin Xu; Sheng Ding; Pentao Liu; Adam Patterson; Garth Cooper; Donghai Wu
Journal:  Sci Rep       Date:  2016-11-02       Impact factor: 4.379

5.  Tissue-Specific Oxidative Stress Modulation by Exercise: A Comparison between MICT and HIIT in an Obese Rat Model.

Authors:  Carole Groussard; Florie Maillard; Emilie Vazeille; Nicolas Barnich; Pascal Sirvent; Yolanda F Otero; Lydie Combaret; Elise Madeuf; Antoine Sourdrille; Geoffroy Delcros; Monique Etienne; Allison Teixeira; Pierre Sauvanet; Vincent Pialoux; Nathalie Boisseau
Journal:  Oxid Med Cell Longev       Date:  2019-07-14       Impact factor: 6.543
  5 in total

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