Literature DB >> 17486378

Influence of amphotericin B and amphotericin B colloidal dispersion on the functions of human phagocytes in defence against Aspergillus species.

S Perkhofer1, G Blum, C Speth, A Mayr, M P Dierich, C Lass-Flörl.   

Abstract

This study investigated the in vitro effects of amphotericin B and amphotericin B colloidal dispersion (ABCD) on phagocytosis and inhibition of germination of clinical isolates of Aspergillus spp. by monocyte-derived macrophages (MDMs). Both amphotericin B and ABCD caused significant reductions in uptake of conidia of Aspergillus spp. by MDMs (p < 0.01). The inhibition of germination was superior with conidia of Aspergillus fumigatus, Aspergillus niger and Aspergillus terreus isolates. Aspergillus flavus growth was significantly less inhibited of either antimycotic as compared to A. fumigatus and A. terreus (p < 0.01).We demonstrate that amphotericin B or ABCD acts as a potent inhibitor of Aspergillus germination. By contrast, treatment of MDMs with these antimycotics diminished phagocytosis of conidia in vitro.

Entities:  

Mesh：

Substances：

Year:  2007        PMID： 17486378     DOI： 10.1007/s10096-007-0300-x

Source DB:  PubMed          Journal:  Eur J Clin Microbiol Infect Dis        ISSN： 0934-9723            Impact factor:   5.103


  25 in total

Review 1.  Nosocomial fungal infections: a classification for hospital-acquired fungal infections and mycoses arising from endogenous flora or reactivation.

Authors:  T J Walsh; P A Pizzo
Journal:  Annu Rev Microbiol       Date:  1988       Impact factor: 15.500

2.  Impact of previous aspergillosis on the outcome of bone marrow transplantation.

Authors:  F Offner; C Cordonnier; P Ljungman; H G Prentice; D Engelhard; D De Bacquer; F Meunier; B De Pauw
Journal:  Clin Infect Dis       Date:  1998-05       Impact factor: 9.079

3.  Prolonged granulocytopenia: the major risk factor for invasive pulmonary aspergillosis in patients with acute leukemia.

Authors:  S L Gerson; G H Talbot; S Hurwitz; B L Strom; E J Lusk; P A Cassileth
Journal:  Ann Intern Med       Date:  1984-03       Impact factor: 25.391

4.  Voriconazole versus amphotericin B for primary therapy of invasive aspergillosis.

Authors:  Raoul Herbrecht; David W Denning; Thomas F Patterson; John E Bennett; Reginald E Greene; Jörg-W Oestmann; Winfried V Kern; Kieren A Marr; Patricia Ribaud; Olivier Lortholary; Richard Sylvester; Robert H Rubin; John R Wingard; Paul Stark; Christine Durand; Denis Caillot; Eckhard Thiel; Pranatharthi H Chandrasekar; Michael R Hodges; Haran T Schlamm; Peter F Troke; Ben de Pauw
Journal:  N Engl J Med       Date:  2002-08-08       Impact factor: 91.245

5.  In vivo bronchoalveolar macrophage defense against Rhizopus oryzae and Aspergillus fumigatus.

Authors:  A R Waldorf; S M Levitz; R D Diamond
Journal:  J Infect Dis       Date:  1984-11       Impact factor: 5.226

6.  Caspofungin versus liposomal amphotericin B for empirical antifungal therapy in patients with persistent fever and neutropenia.

Authors:  Thomas J Walsh; Hedy Teppler; Gerald R Donowitz; Johan A Maertens; Lindsey R Baden; Anna Dmoszynska; Oliver A Cornely; Michael R Bourque; Robert J Lupinacci; Carole A Sable; Ben E dePauw
Journal:  N Engl J Med       Date:  2004-09-30       Impact factor: 91.245

7.  Comparative and collaborative evaluation of standardization of antifungal susceptibility testing for filamentous fungi.

Authors:  A Espinel-Ingroff; K Dawson; M Pfaller; E Anaissie; B Breslin; D Dixon; A Fothergill; V Paetznick; J Peter; M Rinaldi
Journal:  Antimicrob Agents Chemother       Date:  1995-02       Impact factor: 5.191

8.  Dendritic cells transmit human immunodeficiency virus type 1 to monocytes and monocyte-derived macrophages.

Authors:  L Kacani; I Frank; M Spruth; M G Schwendinger; B Müllauer; G M Sprinzl; F Steindl; M P Dierich
Journal:  J Virol       Date:  1998-08       Impact factor: 5.103

9.  Effects of macrophage colony-stimulating factor on antifungal activity of mononuclear phagocytes against Aspergillus fumigatus.

Authors:  E Roilides; T Sein; A Holmes; S Chanock; C Blake; P A Pizzo; T J Walsh
Journal:  J Infect Dis       Date:  1995-10       Impact factor: 5.226

10.  Pulmonary aspergillosis in the acquired immunodeficiency syndrome.

Authors:  D W Denning; S E Follansbee; M Scolaro; S Norris; H Edelstein; D A Stevens
Journal:  N Engl J Med       Date:  1991-03-07       Impact factor: 91.245
View more
  1 in total

1.  Pulmonary epithelial lining fluid concentrations after use of systemic amphotericin B lipid formulations.

Authors:  Stefan Weiler; Gerda Falkensammer; Angelika Hammerer-Lercher; Markus Anliker; Helene Vogelsinger; Michael Joannidis; Stefan Dunzendorfer; Markus Stein; Romuald Bellmann
Journal:  Antimicrob Agents Chemother       Date:  2009-08-24       Impact factor: 5.191
  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.