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Literature DB >> 17485395

Triplex DNA and human disease.

Abstract

Mutagenesis is the fulcrum for the balance between the fidelity of the genetic code and evolution. While there are an enormous number of extrinsic factors driving mutagenesis, alternative DNA secondary structure is one of the intrinsic components that impacts regional genomic stability. Some alternative DNA structures are associated with human diseases, and this review focuses on disease-associated polypurine polypyrimidine mirror repeat sequences.

Entities: Chemical Species

Mesh：

Substances：
triplex DNA
DNA

Year: 2007 PMID： 17485395 DOI： 10.2741/2408

Source DB: PubMed Journal: Front Biosci ISSN： 1093-4715

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Cited

19 in total

Review 1. Targeting DNA G-quadruplex structures with peptide nucleic acids.

Authors: Igor G Panyutin; Mykola I Onyshchenko; Ethan A Englund; Daniel H Appella; Ronald D Neumann
Journal: Curr Pharm Des Date: 2012 Impact factor: 3.116

2. FANCJ uses its motor ATPase to destabilize protein-DNA complexes, unwind triplexes, and inhibit RAD51 strand exchange.

Authors: Joshua A Sommers; Nina Rawtani; Rigu Gupta; Dmitry V Bugreev; Alexander V Mazin; Sharon B Cantor; Robert M Brosh
Journal: J Biol Chem Date: 2009-01-16 Impact factor: 5.157

3. Chromosome fragility at GAA tracts in yeast depends on repeat orientation and requires mismatch repair.

Authors: Hyun-Min Kim; Vidhya Narayanan; Piotr A Mieczkowski; Thomas D Petes; Maria M Krasilnikova; Sergei M Mirkin; Kirill S Lobachev
Journal: EMBO J Date: 2008-10-02 Impact factor: 11.598

Review 4. Potential in vivo roles of nucleic acid triple-helices.

Authors: Fabian A Buske; John S Mattick; Timothy L Bailey
Journal: RNA Biol Date: 2011-05-01 Impact factor: 4.652

5. Replication fork stalling and checkpoint activation by a PKD1 locus mirror repeat polypurine-polypyrimidine (Pu-Py) tract.

Authors: Guoqi Liu; Sheré Myers; Xiaomi Chen; John J Bissler; Richard R Sinden; Michael Leffak
Journal: J Biol Chem Date: 2012-08-06 Impact factor: 5.157

Triplex DNA and human disease.

Review 1. Targeting DNA G-quadruplex structures with peptide nucleic acids.

2. FANCJ uses its motor ATPase to destabilize protein-DNA complexes, unwind triplexes, and inhibit RAD51 strand exchange.

3. Chromosome fragility at GAA tracts in yeast depends on repeat orientation and requires mismatch repair.

Review 4. Potential in vivo roles of nucleic acid triple-helices.

5. Replication fork stalling and checkpoint activation by a PKD1 locus mirror repeat polypurine-polypyrimidine (Pu-Py) tract.

6. RecQ and RecG helicases have distinct roles in maintaining the stability of polypurine.polypyrimidine sequences.

7. Analysis of PKD1 for genomic deletion by multiplex ligation-dependent probe assay: absence of hot spots.

Review 8. DNA triple helices: biological consequences and therapeutic potential.

9. Human replication protein A melts a DNA triple helix structure in a potent and specific manner.

10. Molecular docking of intercalators and groove-binders to nucleic acids using Autodock and Surflex.