Literature DB >> 17485355

Wnt pathway and breast cancer.

Sonia Mohinta1, Hailong Wu, Priyasri Chaurasia, Kounosuke Watabe.   

Abstract

Breast cancer is one of the most debilitating human carcinomas with second highest mortality rate after lung cancer in women. Recent advancement in genetic and biochemical analyses has deciphered the molecular pathways involved in breast cancer development. Wnt signal has long been established to play a critical role in normal development as well as in tumorigenesis. In this review, we summarize the role of Wnt signal in the development of mammary carcinoma, the molecular mechanism via which Wnt signal exerts its malignant potential and various nodal points in the Wnt cascade that can be targeted for drug development and cancer treatment.

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Year:  2007        PMID： 17485355     DOI： 10.2741/2368

Source DB:  PubMed          Journal:  Front Biosci        ISSN： 1093-4715


  30 in total

Review 1.  Ring finger protein 146/Iduna is a poly(ADP-ribose) polymer binding and PARsylation dependent E3 ubiquitin ligase.

Authors:  Zhi-dong Zhou; Christine Hui-shan Chan; Zhi-cheng Xiao; Eng-king Tan
Journal:  Cell Adh Migr       Date:  2011 Nov-Dec       Impact factor: 3.405

2.  Regulation of breast cancer-induced bone lesions by β-catenin protein signaling.

Authors:  Yan Chen; Heidi Y Shi; Stuart R Stock; Paula H Stern; Ming Zhang
Journal:  J Biol Chem       Date:  2011-10-18       Impact factor: 5.157

3.  MiR-145 inhibits tumor angiogenesis and growth by N-RAS and VEGF.

Authors:  Chao Zou; Qing Xu; Feng Mao; Dan Li; Chuanxiu Bian; Ling-Zhi Liu; Yue Jiang; Xiaona Chen; Yanting Qi; Xiaolong Zhang; Xuejing Wang; Qiang Sun; Hsiang-Fu Kung; Marie C Lin; Andreas Dress; Fiona Wardle; Bing-Hua Jiang; Lihui Lai
Journal:  Cell Cycle       Date:  2012-06-01       Impact factor: 4.534

4.  Inhibition of Mouse Breast Tumor-Initiating Cells by Calcitriol and Dietary Vitamin D.

Authors:  Youngtae Jeong; Srilatha Swami; Aruna V Krishnan; Jasmaine D Williams; Shanique Martin; Ronald L Horst; Megan A Albertelli; Brian J Feldman; David Feldman; Maximilian Diehn
Journal:  Mol Cancer Ther       Date:  2015-05-01       Impact factor: 6.261

5.  Methylation-associated silencing of SFRP1 with an 8p11-12 amplification inhibits canonical and non-canonical WNT pathways in breast cancers.

Authors:  Zeng-Quan Yang; Gang Liu; Aliccia Bollig-Fischer; Ramsi Haddad; Adi L Tarca; Stephen P Ethier
Journal:  Int J Cancer       Date:  2009-10-01       Impact factor: 7.396

6.  Dysregulation of WNT/CTNNB1 and PI3K/AKT signaling in testicular stromal cells causes granulosa cell tumor of the testis.

Authors:  Alexandre Boyer; Marilène Paquet; Marie-Noëlle Laguë; Louis Hermo; Derek Boerboom
Journal:  Carcinogenesis       Date:  2009-02-23       Impact factor: 4.944

7.  Frzb, a secreted Wnt antagonist, decreases growth and invasiveness of fibrosarcoma cells associated with inhibition of Met signaling.

Authors:  Yi Guo; Jun Xie; Elyssa Rubin; Ya-Xiong Tang; Fritz Lin; Xiaolin Zi; Bang H Hoang
Journal:  Cancer Res       Date:  2008-05-01       Impact factor: 12.701

Review 8.  Epigenetic gene regulation in stem cells and correlation to cancer.

Authors:  Lesley A Mathews; Francesco Crea; W L Farrar
Journal:  Differentiation       Date:  2009-05-14       Impact factor: 3.880

9.  Genetic mechanisms in Apc-mediated mammary tumorigenesis.

Authors:  Mari Kuraguchi; Nana Yaw Ohene-Baah; Dmitriy Sonkin; Roderick Terry Bronson; Raju Kucherlapati
Journal:  PLoS Genet       Date:  2009-02-06       Impact factor: 5.917

10.  Cooperation of Notch and Ras/MAPK signaling pathways in human breast carcinogenesis.

Authors:  Suruchi Mittal; Deepa Subramanyam; Devaveena Dey; Rekha V Kumar; Annapoorni Rangarajan
Journal:  Mol Cancer       Date:  2009-12-23       Impact factor: 27.401
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