Literature DB >> 174853

Immunological cross-reactivity between basic proteins of myelin and cancer. I. Lymphocyte transformation studies in immunized guinea-pigs.

A S Coates, P R Carnegie.   

Abstract

The studies described were designed to examine the question of cross-reactivity between basic protein of myelin and a basic protein common to many human tumours. The lymphocytes from guinea-pigs injected with acid extracts of human cancer tissue showed significant (P less than 0-01) tranformation on exposure to basic protein of human myelin. Conversely lymphocytes from guinea-pigs injected with basic protein of human myelin showed significant (P less than 0-01) transformation on exposure to the acid extracts of human cancer tissue. Lymphocytes from control non-injected guinea-pigs did not transform on exposure to either antigen. These findings demonstrate immunological cross-reactivity in guinea-pigs between basic proteins of human myelin and of human cancer tissue using an assay system other than the macrophage electrophoretic migration hitherto used to show this effect in man.

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Year:  1975        PMID： 174853      PMCID： PMC1538324     

Source DB:  PubMed          Journal:  Clin Exp Immunol        ISSN： 0009-9104            Impact factor:   4.330


  17 in total

1.  Depression of cell-mediated immunity in old age and the immunopathic diseases, lupus erythematosus, chronic hepatitis and rheumatoid arthritis.

Authors:  B H Toh; I C Roberts-Thomson; J D Mathews; S Whittingham; I R Mackay
Journal:  Clin Exp Immunol       Date:  1973-06       Impact factor: 4.330

2.  Histones and cancer test.

Authors:  E W Johns; J A Pritchard; J L Moore; W H Sutherland; C A Joslin; J A Forrester; A J Davies; A M Neville; R G Fish
Journal:  Nature       Date:  1973-09-14       Impact factor: 49.962

3.  Properties of antibodies produced in rabbits to human myelin and myelin basic protein.

Authors:  S Whittingham; B Bencina; P R Carnegie; T A McPherson
Journal:  Int Arch Allergy Appl Immunol       Date:  1972

4.  No evidence for an immunological cross-reaction between encephalitogenic myelin basic protein and histones.

Authors:  G Schmid; G Thomas; H W Lange; K Hempel
Journal:  Int Arch Allergy Appl Immunol       Date:  1974

5.  The macrophage electrophoretic migration test in cancer.

Authors:  A H Goldstone; L Kerr; W J Irvine
Journal:  Clin Exp Immunol       Date:  1973-07       Impact factor: 4.330

6.  Cellular-immune response to myelin protein: absence in multiple sclerosis and presence in cerebrovascular accidents.

Authors:  U Youngchaiyud; A S Coates; S Whittingham; I R Mackay
Journal:  Aust N Z J Med       Date:  1974-12

7.  Radioimmunoassay with gel filtration for detecting antibody to basic proteins of myelin.

Authors:  T A McPherson; P R Carnegie
Journal:  J Lab Clin Med       Date:  1968-11

8.  Lymphocyte sensitisation: an in-vitro test for cancer?

Authors:  E J Field; E A Caspary
Journal:  Lancet       Date:  1970-12-26       Impact factor: 79.321

9.  The macrophage electrophoretic mobility (MEM) test for malignant disease. Further clinical investigations and studies on macrophage slowing factors.

Authors:  A W Preece; P A Light
Journal:  Clin Exp Immunol       Date:  1974-12       Impact factor: 4.330

10.  Large scale preparation of myelin basic protein from central nervous tissue of several mammalian species.

Authors:  G E Deibler; R E Martenson; M W Kies
Journal:  Prep Biochem       Date:  1972
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  5 in total

1.  Cerebellar cortical degeneration with ovarian carcinoma.

Authors:  M M Steven; I R Mackay; P R Carnegie; P S Bhathal; R M Anderson
Journal:  Postgrad Med J       Date:  1982-01       Impact factor: 2.401

2.  Failure to induce transplantation immunity to an SV40-induced tumour in hamsters immunized with basic proteins of myelin or malignant tissues.

Authors:  D J Flavell; C W Potter
Journal:  Br J Cancer       Date:  1978-07       Impact factor: 7.640

3.  Cell-mediated immunity to encephalitogenic factor (MMI test) in women with cervical dysplasia and carcinoma in situ: the effects of serum.

Authors:  D J Flavell; A Singer; C W Potter
Journal:  Br J Cancer       Date:  1978-09       Impact factor: 7.640

4.  Responses of cancer patients in the MEM test: not just a function of charge on basic proteins.

Authors:  A Shaw; G Ettin; T A McPherson
Journal:  Br J Cancer       Date:  1976-07       Impact factor: 7.640

5.  Cellular immunity to encephalitogenic factor in man as measured by the macrophage migration inhibition test: the effects of serum.

Authors:  D J Flavell; C W Potter
Journal:  Br J Cancer       Date:  1978-01       Impact factor: 7.640
  5 in total

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