Literature DB >> 17485209

RXR-LXR heterodimer modulators for the potential treatment of dyslipidemia.

Bharat Lagu1, Barbara Pio, Rimma Lebedev, Maria Yang, Patricia D Pelton.   

Abstract

A number of RXR agonists were synthesized and screened in functional assays. The synthesis and the structure-activity relationship (SAR) within the series of compounds will be presented. Some in vivo data in rodent models for dyslipidemia and diabetes will also be presented.

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Year:  2007        PMID: 17485209     DOI: 10.1016/j.bmcl.2007.01.047

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  3 in total

1.  Retinoic acid synthesis and functions in early embryonic development.

Authors:  Richard Kin Ting Kam; Yi Deng; Yonglong Chen; Hui Zhao
Journal:  Cell Biosci       Date:  2012-03-22       Impact factor: 7.133

2.  Synthesis and Fungicidal Activity of 1-(Carbamoylmethyl)-2-aryl-3,1-benzoxazines.

Authors:  Zi-Long Tang; Lian Wang; Jing-Zhao Tan; Yi-Chao Wan; Yin-Chun Jiao
Journal:  Molecules       Date:  2017-07-06       Impact factor: 4.411

3.  Comprehensive Set of Tertiary Complex Structures and Palmitic Acid Binding Provide Molecular Insights into Ligand Design for RXR Isoforms.

Authors:  Apirat Chaikuad; Julius Pollinger; Michael Rühl; Xiaomin Ni; Whitney Kilu; Jan Heering; Daniel Merk
Journal:  Int J Mol Sci       Date:  2020-11-11       Impact factor: 5.923

  3 in total

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