OBJECTIVES: The objectives were to assess the prevalence of high-risk HPV in the male sexual partners of women with HPV-induced lesions, and correlate it with biopsies guided by peniscopy. STUDY DESIGN: Fifty-four asymptomatic male sexual partners of women with low-grade squamous intra-epithelial lesions (LSIL) associated with high-risk HPV were examined between April 2003 and June 2005. The DNA-HPV was tested using a second-generation hybrid capture technique in scraped penile samples. Peniscopy identified acetowhite lesions leading to biopsy. RESULTS: High-risk HPV was present in 25.9% (14 out of 54) of the cases. Peniscopy led to 13 biopsies (24.07%), which resulted in two cases of condyloma, two cases of intra-epithelial neoplasia (PIN) I, one case of PIN II, and eight cases of normal tissue. The high-risk HPV test demonstrated 80% sensitivity, 100% specificity, 100% positive predictive value, and 88.9% negative predictive value for the identification of penile lesions. There was a greater chance of finding HPV lesions in the biopsy in the positive cases of high-risk HPV with abnormal peniscopy (p=0.007); OR=51 (CI 1.7-1527.1). CONCLUSION: Among asymptomatic male sexual partners of women with low-grade intra-epithelial squamous lesions, those infected by high-risk HPV have a higher chance of having abnormal penile tissue compared with male partners without that infection.
OBJECTIVES: The objectives were to assess the prevalence of high-risk HPV in the male sexual partners of women with HPV-induced lesions, and correlate it with biopsies guided by peniscopy. STUDY DESIGN: Fifty-four asymptomatic male sexual partners of women with low-grade squamous intra-epithelial lesions (LSIL) associated with high-risk HPV were examined between April 2003 and June 2005. The DNA-HPV was tested using a second-generation hybrid capture technique in scraped penile samples. Peniscopy identified acetowhite lesions leading to biopsy. RESULTS: High-risk HPV was present in 25.9% (14 out of 54) of the cases. Peniscopy led to 13 biopsies (24.07%), which resulted in two cases of condyloma, two cases of intra-epithelial neoplasia (PIN) I, one case of PIN II, and eight cases of normal tissue. The high-risk HPV test demonstrated 80% sensitivity, 100% specificity, 100% positive predictive value, and 88.9% negative predictive value for the identification of penile lesions. There was a greater chance of finding HPV lesions in the biopsy in the positive cases of high-risk HPV with abnormal peniscopy (p=0.007); OR=51 (CI 1.7-1527.1). CONCLUSION: Among asymptomatic male sexual partners of women with low-grade intra-epithelial squamous lesions, those infected by high-risk HPV have a higher chance of having abnormal penile tissue compared with male partners without that infection.
Authors: Maria Gabrielle de Lima Rocha; Fabio Lopes Faria; Leonor Gonçalves; Maria do Carmo M Souza; Paula Ávila Fernandes; Ana Paula Fernandes Journal: PLoS One Date: 2012-07-17 Impact factor: 3.240
Authors: L A Afonso; W M Rocha; F N Carestiato; E A Dobao; L F Pesca; M R L Passos; S M B Cavalcanti Journal: Braz J Med Biol Res Date: 2013-05-24 Impact factor: 2.590
Authors: Elena Lopez-Diez; Sonia Perez; Manuel Carballo; Amparo Iñarrea; Angel de la Orden; Maximo Castro; Moises Rodríguez; Sheila Almuster; Ruben Montero; Miguel Perez; Jorge Sanchez; Antonio Ojea Journal: PLoS One Date: 2017-09-12 Impact factor: 3.240
Authors: Roberto Jose Carvalho da Silva; Staci Lynn Sudenga; Laura Sichero; Maria Luiza Baggio; Lenice Galan; Ricardo Cintra; Benji Nelson Torres; Mark Stoler; Anna Regina Giuliano; Luisa Lina Villa Journal: Braz J Infect Dis Date: 2017-04-08 Impact factor: 3.257