| Literature DB >> 17485145 |
Sandrine Delarue-Cochin1, Emilia Paunescu, Louis Maes, Elisabeth Mouray, Christian Sergheraert, Philippe Grellier, Patricia Melnyk.
Abstract
In order to determine the real significance of the 4'-phenolic group in the antimalarial activity and/or cytotoxicity of amodiaquine (AQ), analogues for which this functionality was shifted or modified were synthesized. Good in vitro antimalarial activity was obtained for compounds unable to form intramolecular hydrogen bond. Among the compounds synthesized, new amino derivative 5 displayed the greatest selectivity index towards the most CQ-resistant strain tested and was active in mice infected by Plasmodium berghei.Entities:
Mesh：
Substances：
Year: 2007 PMID： 17485145 DOI： 10.1016/j.ejmech.2007.03.008
Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514