BACKGROUND: In dermoscopy the presence of a blue hue is a clue for malignancy, although a blue tint is sometimes observable in benign lesions. OBJECTIVE: To identify the in vivo confocal microscopy correlates of the blue hue for improving diagnostic accuracy for melanoma. METHODS: Fifty-seven melanomas, 41 junctional, 88 compound, and 27 Spitz nevi were studied by dermoscopy, confocal microscopy, and histopathology. RESULTS: Confocal microscopy enabled the distinction between blue areas and blue veil, the former characterized by plump cells corresponding to melanophages and inflammatory infiltrate at histology, the latter by the contemporary presence of epidermal and dermal features consistent with diagnosis of melanoma, such as disarranged pattern, pagetoid cells, cytologic and architectural atypias, nonhomogeneous and cerebriform clusters, and dermal nucleated cells. LIMITATIONS: Confocal microscopy failed to accurately distinguish Spitz nevi, because of the presence of cytoarchitectural disarray in the epidermis and the upper dermis. CONCLUSION: Confocal microscopy enabled the in vivo identification of characteristic cytological substrates correlated with the blue features in dermoscopy.
BACKGROUND: In dermoscopy the presence of a blue hue is a clue for malignancy, although a blue tint is sometimes observable in benign lesions. OBJECTIVE: To identify the in vivo confocal microscopy correlates of the blue hue for improving diagnostic accuracy for melanoma. METHODS: Fifty-seven melanomas, 41 junctional, 88 compound, and 27 Spitz nevi were studied by dermoscopy, confocal microscopy, and histopathology. RESULTS: Confocal microscopy enabled the distinction between blue areas and blue veil, the former characterized by plump cells corresponding to melanophages and inflammatory infiltrate at histology, the latter by the contemporary presence of epidermal and dermal features consistent with diagnosis of melanoma, such as disarranged pattern, pagetoid cells, cytologic and architectural atypias, nonhomogeneous and cerebriform clusters, and dermal nucleated cells. LIMITATIONS: Confocal microscopy failed to accurately distinguish Spitz nevi, because of the presence of cytoarchitectural disarray in the epidermis and the upper dermis. CONCLUSION: Confocal microscopy enabled the in vivo identification of characteristic cytological substrates correlated with the blue features in dermoscopy.
Authors: Alice Casari; Giovanni Pellacani; Stefania Seidenari; Anna Maria Cesinaro; Francesca Beretti; Patrizia Pepe; Caterina Longo Journal: J Skin Cancer Date: 2010-10-14
Authors: Cristian Navarrete-Dechent; Konstantinos Liopyris; Jilliana Monnier; Saud Aleissa; Lindsay M Boyce; Caterina Longo; Margaret Oliviero; Harold Rabinovitz; Ashfaq A Marghoob; Allan C Halpern; Giovanni Pellacani; Alon Scope; Manu Jain Journal: J Am Acad Dermatol Date: 2020-05-23 Impact factor: 11.527
Authors: Jacqueline Dinnes; Jonathan J Deeks; Naomi Chuchu; Rubeta N Matin; Kai Yuen Wong; Roger Benjamin Aldridge; Alana Durack; Abha Gulati; Sue Ann Chan; Louise Johnston; Susan E Bayliss; Jo Leonardi-Bee; Yemisi Takwoingi; Clare Davenport; Colette O'Sullivan; Hamid Tehrani; Hywel C Williams Journal: Cochrane Database Syst Rev Date: 2018-12-04
Authors: Jacqueline Dinnes; Jonathan J Deeks; Naomi Chuchu; Lavinia Ferrante di Ruffano; Rubeta N Matin; David R Thomson; Kai Yuen Wong; Roger Benjamin Aldridge; Rachel Abbott; Monica Fawzy; Susan E Bayliss; Matthew J Grainge; Yemisi Takwoingi; Clare Davenport; Kathie Godfrey; Fiona M Walter; Hywel C Williams Journal: Cochrane Database Syst Rev Date: 2018-12-04