Literature DB >> 17485090

Sialic acid is an essential moiety of mucin as a hydroxyl radical scavenger.

Yuki Ogasawara1, Tomoyuki Namai, Fumihiko Yoshino, Masaichi-Chang-il Lee, Kazuyuki Ishii.   

Abstract

In this work, we examined the antioxidant role of mucin, a typical sialic acid containing high-molecular weight glycoprotein. The function of mucin as a hydroxyl radical (.OH) scavenger was characterized using bovine submaxillary gland mucin (BSM). Non-treated BSM effectively protected DNA from the attack of .OH; however, desialylated BSM lost this potential. Moreover, we estimated the scavenging effects of BSM against .OH generated by UV irradiation of hydrogen peroxide using ESR analysis. Our results indicate that BSM has .OH scavenging ability the and sialic acid in mucin is an essential moiety to scavenge .OH.

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Year:  2007        PMID： 17485090     DOI： 10.1016/j.febslet.2007.04.062

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  23 in total

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10.  Deletion of the lactoperoxidase gene causes multisystem inflammation and tumors in mice.

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