| Literature DB >> 17485084 |
Tomoko Igarashi1, Satohiko Araki, Hidezo Mori, Soichi Takeda.
Abstract
Catrocollastatin/vascular apoptosis-inducing protein (VAP)2B is a metalloproteinase from Crotalus atrox venom, possessing metalloproteinase/disintegrin/cysteine-rich (MDC) domains that bear the typical domain architecture of a disintegrin and metalloproteinase (ADAM)/adamalysin/reprolysin family proteins. Here we describe crystal structures of catrocollastatin/VAP2B in three different crystal forms, representing the first reported crystal structures of a member of the monomeric class of this family of proteins. The overall structures show good agreement with both monomers of atypical homodimeric VAP1. Comparison of the six catrocollastatin/VAP2B monomer structures and the structures of VAP1 reveals a dynamic, modular architecture that may be important for the functions of ADAM/adamalysin/reprolysin family proteins.Mesh：
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Year: 2007 PMID： 17485084 DOI： 10.1016/j.febslet.2007.04.057
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124