Tomer T Levin1, Yuelin Li, John Riskind, Kanti Rai. 1. Department of Psychiatry and Behavioral Sciences, Memorial Sloan-Kettering Cancer Center, New York, NY 10022, USA. levint@mskcc.org
Abstract
OBJECTIVE: Although chronic lymphocytic leukemia (CLL) accounts for 25-30% of leukemia cases, little is known about its psychosocial correlates. This study examines anxiety, depression and quality of life (QOL) in a CLL cohort. METHODS: One hundred five patients recruited from a CLL research database were classified into two groups: "watch and wait" or active treatment. The patients completed a mail-in battery of depression, anxiety and QOL measures. RESULTS: There was no statistical difference between depression, anxiety and physical/mental QOL in "watch and wait" versus active-treatment groups. Patients < or =60 years reported more depression (P=.014) and worse emotional (P=.0001) and social QOL (P=.002). They also had more "watch and wait" anxiety (P=.052). Social and emotional QOL were similar in both newly diagnosed patients and those diagnosed >6 years ago, although physical QOL worsens with time (P=.05). CONCLUSION: Depression, anxiety and QOL are remarkably similar in "watch and wait" versus actively treated CLL, despite the latter group having, by definition, later stage disease. Patients < or =60 years are more depressed and have reduced emotional and social QOL. Younger "watch and wait" patients are more anxious. Patients diagnosed for more than 6 years have a worse physical QOL, but their social and emotional QOL are similar to those of newly diagnosed patients.
OBJECTIVE: Although chronic lymphocytic leukemia (CLL) accounts for 25-30% of leukemia cases, little is known about its psychosocial correlates. This study examines anxiety, depression and quality of life (QOL) in a CLL cohort. METHODS: One hundred five patients recruited from a CLL research database were classified into two groups: "watch and wait" or active treatment. The patients completed a mail-in battery of depression, anxiety and QOL measures. RESULTS: There was no statistical difference between depression, anxiety and physical/mental QOL in "watch and wait" versus active-treatment groups. Patients < or =60 years reported more depression (P=.014) and worse emotional (P=.0001) and social QOL (P=.002). They also had more "watch and wait" anxiety (P=.052). Social and emotional QOL were similar in both newly diagnosed patients and those diagnosed >6 years ago, although physical QOL worsens with time (P=.05). CONCLUSION:Depression, anxiety and QOL are remarkably similar in "watch and wait" versus actively treated CLL, despite the latter group having, by definition, later stage disease. Patients < or =60 years are more depressed and have reduced emotional and social QOL. Younger "watch and wait" patients are more anxious. Patients diagnosed for more than 6 years have a worse physical QOL, but their social and emotional QOL are similar to those of newly diagnosed patients.
Authors: Barbara L Andersen; Neha Godiwala Goyal; David M Weiss; Travis D Westbrook; Kami J Maddocks; John C Byrd; Amy J Johnson Journal: Cancer Date: 2018-05-14 Impact factor: 6.860
Authors: Abigail S Robbertz; David M Weiss; Farrukh T Awan; John C Byrd; Kerry A Rogers; Jennifer A Woyach Journal: Support Care Cancer Date: 2019-07-22 Impact factor: 3.603
Authors: Travis D Westbrook; Eleshia J Morrison; Kami J Maddocks; Farrukh T Awan; Jeffrey A Jones; Jennifer A Woyach; Amy J Johnson; John C Byrd; Barbara L Andersen Journal: Ann Behav Med Date: 2019-08-16