Congenital malaria: the least known consequence of malaria in pregnancy.

Congenital malaria is the least known manifestation of malaria and a very neglected area of research. Most of the existing information is limited to case reports in children born to non-immune women. With the use of molecular techniques, congenital infection is being increasingly detected among infants born to semi-immune women in endemic countries. However, many gaps in knowledge remain. The mechanisms and timing of infection are unclear. Furthermore, there is a lack of information on the impact of congenital malaria infection on the subsequent risk of malaria and general morbidity in the infant. There is also a lack of consensus on the clinical guidelines for its management. More research is needed in order to establish adequate preventive and management recommendations to avoid this consequence of malaria in pregnancy.