Literature DB >> 17482889

MGMT: a personal perspective.

Sankar Mitra1.   

Abstract

This review describes the history of studies on alkylation damage of mammalian genomes and its carcinogenic consequences that led to the discovery of a unique DNA repair protein, named MGMT. MGMT repairs O(6)-alkylguanine, a critical mutagenic lesion induced by alkylating agents. The follow-up studies in mammalian cells following the discovery of the ubiquitous repair protein in E. coli are summarized.

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Year:  2007        PMID： 17482889      PMCID： PMC2692271          DOI： 10.1016/j.dnarep.2007.03.007

Source DB:  PubMed          Journal:  DNA Repair (Amst)        ISSN： 1568-7856


  67 in total

Review 1.  Adaptive response of Escherichia coli to alkylation damage.

Authors:  M R Volkert
Journal:  Environ Mol Mutagen       Date:  1988       Impact factor: 3.216

2.  Carcinogenicity of N-methyl-N-nitrosourea: possible role of excision repair of O6-methylguanine from DNA.

Authors:  P Kleihues; G P Margison
Journal:  J Natl Cancer Inst       Date:  1974-12       Impact factor: 13.506

Review 3.  Regulation of repair of alkylation damage in mammalian genomes.

Authors:  S Mitra; B Kaina
Journal:  Prog Nucleic Acid Res Mol Biol       Date:  1993

4.  The inducible repair of alkylated DNA.

Authors:  J Cairns; P Robins; B Sedgwick; P Talmud
Journal:  Prog Nucleic Acid Res Mol Biol       Date:  1981

5.  Apoptosis induced by DNA damage O6-methylguanine is Bcl-2 and caspase-9/3 regulated and Fas/caspase-8 independent.

Authors:  K Ochs; B Kaina
Journal:  Cancer Res       Date:  2000-10-15       Impact factor: 12.701

6.  The AidB component of the Escherichia coli adaptive response to alkylating agents is a flavin-containing, DNA-binding protein.

Authors:  Mukta S Rohankhedkar; Scott B Mulrooney; William J Wedemeyer; Robert P Hausinger
Journal:  J Bacteriol       Date:  2006-01       Impact factor: 3.490

7.  Kinetics of incorporation of O6-methyldeoxyguanosine monophosphate during in vitro DNA synthesis.

Authors:  E T Snow; R S Foote; S Mitra
Journal:  Biochemistry       Date:  1984-09-11       Impact factor: 3.162

8.  Characterization of cDNA encoding mouse DNA repair protein O6-methylguanine-DNA methyltransferase and high-level expression of the wild-type and mutant proteins in Escherichia coli.

Authors:  S Shiota; M A von Wronski; K Tano; D D Bigner; T P Brent; S Mitra
Journal:  Biochemistry       Date:  1992-02-25       Impact factor: 3.162

9.  Regulation of expression of the ada gene controlling the adaptive response. Interactions with the ada promoter of the Ada protein and RNA polymerase.

Authors:  K Sakumi; M Sekiguchi
Journal:  J Mol Biol       Date:  1989-01-20       Impact factor: 5.469

10.  Treatment of human brain tumor xenografts with O6-benzyl-2'-deoxyguanosine and BCNU.

Authors:  S C Schold; D M Kokkinakis; J L Rudy; R C Moschel; A E Pegg
Journal:  Cancer Res       Date:  1996-05-01       Impact factor: 12.701
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  15 in total

1.  p53-Mediated down-regulation of the human DNA repair gene O6-methylguanine-DNA methyltransferase (MGMT) via interaction with Sp1 transcription factor.

Authors:  Dora Bocangel; Shiladitya Sengupta; Sankar Mitra; Kishor K Bhakat
Journal:  Anticancer Res       Date:  2009-10       Impact factor: 2.480

2.  Quantification of DNA Lesions Induced by 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol in Mammalian Cells.

Authors:  Su Guo; Jiapeng Leng; Ying Tan; Nathan E Price; Yinsheng Wang
Journal:  Chem Res Toxicol       Date:  2019-02-15       Impact factor: 3.739

3.  Distinct pathways for repairing mutagenic lesions induced by methylating and ethylating agents.

Authors:  Kentaro Taira; Satomi Kaneto; Kota Nakano; Shinji Watanabe; Eizo Takahashi; Sakae Arimoto; Keinosuke Okamoto; Roel M Schaaper; Kazuo Negishi; Tomoe Negishi
Journal:  Mutagenesis       Date:  2013-02-27       Impact factor: 3.000

4.  Cytotoxic and mutagenic properties of O 6-alkyl-2'-deoxyguanosine lesions in Escherichia coli cells.

Authors:  Pengcheng Wang; Yinsheng Wang
Journal:  J Biol Chem       Date:  2018-08-01       Impact factor: 5.157

Review 5.  O(6)-methylguanine-DNA methyltransferase in glioma therapy: promise and problems.

Authors:  John R Silber; Michael S Bobola; A Blank; Marc C Chamberlain
Journal:  Biochim Biophys Acta       Date:  2012-01-08

6.  Rhein Inhibits AlkB Repair Enzymes and Sensitizes Cells to Methylated DNA Damage.

Authors:  Qi Li; Yue Huang; Xichun Liu; Jianhua Gan; Hao Chen; Cai-Guang Yang
Journal:  J Biol Chem       Date:  2016-03-25       Impact factor: 5.157

Review 7.  Functions of disordered regions in mammalian early base excision repair proteins.

Authors:  Muralidhar L Hegde; Tapas K Hazra; Sankar Mitra
Journal:  Cell Mol Life Sci       Date:  2010-08-17       Impact factor: 9.261

8.  Tumor-associated mutations in O⁶ -methylguanine DNA-methyltransferase (MGMT) reduce DNA repair functionality.

Authors:  Kristy L Lamb; Yanfeng Liu; Kimiko Ishiguro; Youngho Kwon; Nicolas Paquet; Alan C Sartorelli; Patrick Sung; Sara Rockwell; Joann B Sweasy
Journal:  Mol Carcinog       Date:  2012-10-12       Impact factor: 4.784

Review 9.  Early steps in the DNA base excision/single-strand interruption repair pathway in mammalian cells.

Authors:  Muralidhar L Hegde; Tapas K Hazra; Sankar Mitra
Journal:  Cell Res       Date:  2008-01       Impact factor: 25.617

10.  Effect of lomeguatrib-temozolomide combination on MGMT promoter methylation and expression in primary glioblastoma tumor cells.

Authors:  Mehmet Taspinar; Seda Ilgaz; Mevci Ozdemir; Tulin Ozkan; Derya Oztuna; Hande Canpinar; Juan A Rey; Asuman Sunguroğlu; Javier S Castresana; Hasan Caglar Ugur
Journal:  Tumour Biol       Date:  2013-03-22
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